N-(3-nitro-phenyl)-glycine amide | 24889-04-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(3-nitro-phenyl)-glycine amide
• 英文别名: N-(3-Nitro-phenyl)-glycin-amid；2-(3-Nitroanilino)acetamide
• CAS: 24889-04-1
• 化学式: C₈H₉N₃O₃
• mdl: MFCD12173634
• 分子量: 195.178
• InChiKey: DUSWJQPBVNMHIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-nitro-phenyl)-glycine amide 、 硫酸二甲酯 生成 N-methyl-N-(3-nitro-phenyl)-glycine amide
  参考文献：
  名称：

  Takeda, Contributions from Boyce Thompson Institute, 1959, vol. 20, p. 197,199

  摘要：

  DOI：

文献信息

• STUDIES ON ORGANOPHOSPHORUS HETERO-CYCLES PART IV. THE REACTION OF LAWESSON'S REAGENT WITH GLYCINAMIDES, SYNTHESIS AND HERBICIDAL ACTIVITY OF 1,3,2-DIAZAPHOS-PHOLIDIN-4-THIONE-2-SULFIDES
  作者：Liang Nian He、Ru-Yu Chen

  DOI：10.1080/10426509708031586

  日期：1997.10.1

  Abstract 2,4-Bis (4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's Reagent) reacts with glycinamides (2a-m) in benzene at 55 ∼ 60°C to give 1,3,2-diazaphospholidin-4-thone-2-sulfides (3a-m). The structure of the products has been confirmed by elementary analyses, NMR, IR, MS and X-ray diffraction. The result of preliminary bioassay indicates that some of the compounds prepared

  摘要 2,4-双（4-甲氧基苯基）-1,3,2,4-二硫代二膦烷-2,4-二硫化物（Lawesson 试剂）与甘氨酰胺（2a-m）在苯中在 55 ∼ 60°C 下反应生成 1 ,3,2-diazaphospholidin-4-thone-2-sulfides (3a-m)。产物的结构已通过元素分析、核磁共振、红外、质谱和X射线衍射证实。初步生物测定结果表明，所制备的部分化合物对rap具有较高的选择性除草活性。
• [EN] PYRIDOPYRIMIDINE DERIVATIVES AS MEK INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDOPYRIMIDINE UTILISÉS COMME INHIBITEURS DE MEK
  申请人：LUPIN LTD

  公开号：WO2016035008A1

  公开（公告）日：2016-03-10

  The present disclosure is related to heterocyclyl compounds as MEK inhibitors. These compounds include heterocyclyl compounds of formula (I), their pharmaceutically acceptable salts, their combinations with suitable medicaments, and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:(I)
• Takeda, Contributions from Boyce Thompson Institute, 1959, vol. 20, p. 197,199
  作者：Takeda

  DOI：——

  日期：——