4-(((3-(dimethylamino)propyl)amino)methyl)phenol | 1020996-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(((3-(dimethylamino)propyl)amino)methyl)phenol
• 英文别名: 4-[[3-(Dimethylamino)propylamino]methyl]phenol
• CAS: 1020996-81-9
• 化学式: C₁₂H₂₀N₂O
• mdl: MFCD11146294
• 分子量: 208.304
• InChiKey: JUPSSTHFCAYLQV-UHFFFAOYSA-N

物化性质

• 沸点：
  330.9±27.0 °C(Predicted)
• 密度：
  1.027±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯甲醛 、 N,N-二甲基-1,3-二氨基丙烷 在 sodium sulfate 、 sodium tetrahydroborate 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 118.0h， 以75%的产率得到4-(((3-(dimethylamino)propyl)amino)methyl)phenol
  参考文献：
  名称：

  N1,N1-Dimethyl-N3-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis

  摘要：

  The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement). (C) 2014 The Authors. Published by Elsevier Masson SAS. All rights

  DOI：

  10.1016/j.ejmech.2013.12.050

文献信息

• HITZEHÄRTENDE EPOXIDHARZKLEBSTOFFE
  申请人：Sika Technology AG

  公开号：EP3630866A1

  公开（公告）日：2020-04-08
• THREE COMPONENT COMPOSITION FOR THE MANUFACTURE OF PRIMER LAYER OR SCRATCH COATING FOR FLOORING
  申请人：Sika Technology AG

  公开号：EP3673001B1

  公开（公告）日：2022-04-27
• [EN] IMIDAZOQUINOLINES WHICH ACT VIA TOLL - LIKE RECEPTORS (TLR)<br/>[FR] IMIDAZOQUINOLINES AGISSANT PAR L'INTERMÉDIAIRE DES RÉCEPTEURS DE TYPE TOLL (TLR)
  申请人：DAINIPPON SUMITOMO PHARMA CO

  公开号：WO2011068233A1

  公开（公告）日：2011-06-09

  The present invention provides compounds of formula (I): wherein Ra, Rb, Rc, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
• [EN] THREE COMPONENT COMPOSITION FOR THE MANUFACTURE OF PRIMER LAYER OR SCRATCH COATING FOR FLOORING<br/>[FR] COMPOSITION À TROIS CONSTITUANTS POUR LA PRODUCTION D'UNE COUCHE D'APPRÊT OU D'UN REVÊTEMENT ANTIRAYURES POUR REVÊTEMENT DE SOL
  申请人：SIKA TECH AG

  公开号：WO2019038340A1

  公开（公告）日：2019-02-28

  The present invention relates to a three component composition consisting of a polyol component (A) comprising at least two polyols, one with high, one with low molecular weight and water, a polyisocyanate component (B) comprising a methylene diphenyl diisocyanate (MDI) product with an average NCO functionality of at least 2.5, or a methylene diphenyl diisocyanate (MDI) product with an average NCO functionality of at least 2 and at least one further polyol with an amount of between 1% and 30% based on the weight of said polyisocyanate component (B), wherein said MDI product and said polyol have reacted at least partially, and a powder component (C) comprising at least one hydraulic binder, preferably cement and/or calcined paper sludge, preferably a calcium compound selected from calcium hydroxide and/or calcium oxide, and optionally one or more aggregates. The composition contains 2-(Dimethylamino)ethanol, whereby the molar ratio of the 2-(Dimethylamino)ethanol to the OH-groups of the polyol P1 a is between 0.0008 and 0.013 and the weight ratio of components (A+B) to component (C) ((A+B)/(C)) is in the range of 2 : 1.5 to 2 : 3.5, wherein components (A+B) represents the combined weight of component (A) and component (B). The inventive three component composition can be used as primer layer or scratch coat for flooring, especially industrial flooring, applications. The inventive three component composition can provide a waterproofing layer on substrates, especially concrete substrates, that enables good adhesion and proper performance of the flooring systems applied onto them. The inventive three component composition exhibits over a broad temperature range from 5 - 35°C good characteristics as to workability and open time.