2-(3-Hydroxyphenyl)-1H-isoindole-1,3-(2H)dione | 59479-66-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(3-Hydroxyphenyl)-1H-isoindole-1,3-(2H)dione
• 英文别名: 2-(3-hydroxyphenyl)isoindoline-1,3-dione；N-(3-Hydroxy-phenyl)-phthalimid；N-(3-hydroxy-phenyl)-phthalimide；2-(3-hydroxyphenyl)isoindole-1,3-dione
• CAS: 59479-66-2
• 化学式: C₁₄H₉NO₃
• mdl: MFCD00187332
• 分子量: 239.23
• InChiKey: FZZOXPGVXDMPMS-UHFFFAOYSA-N

物化性质

• 熔点：
  226 °C
• 沸点：
  474.7±47.0 °C(Predicted)
• 密度：
  1.448±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-Hydroxyphenyl)-1H-isoindole-1,3-(2H)dione 在 四氢呋喃 、 zinc(II) chloride 、 diborane(6) 作用下， 以 乙醇 为溶剂， 反应 34.0h， 生成 7-<2(1H)-Isoindolyl>-4-(trifluoromethyl)coumarin
  参考文献：
  名称：

  一些7-取代的4-（三氟甲基）香豆素

  摘要：

  DOI：

  10.1021/je00025a041
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2-(3-Hydroxyphenyl)-1H-isoindole-1,3-(2H)dione
  参考文献：
  名称：

  Medinger, Journal fur praktische Chemie (Leipzig 1954), 1912, vol. <2>86, # 355, p. 356

  摘要：

  DOI：

文献信息

• “On water” nano-Cu₂O-catalyzed CO-free one-pot multicomponent cascade cyanation–annulation–aminolysis reaction toward phthalimides
  作者：Xiaowei Wen、Xiaojuan Liu、Zhiqi Yang、Menglan Xie、Yuxi Liu、Lipeng Long、Zhengwang Chen

  DOI：10.1039/d1ob00073j

  日期：——

  An efficient nano-Cu2O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as a solvent, affording versatile N-substituted phthalimide derivatives in moderate to excellent yields. This novel strategy features carbon monoxide gas-free, environmentally benign, one-pot multistep transformation, commercially available

  以水为溶剂，开发了2-卤代苯甲酸和三甲基甲硅烷基氰化物与多种胺的高效纳米Cu 2 O催化级联多组分反应，以中等至优异的收率提供了多种N-取代邻苯二甲酰亚胺衍生物。这种新颖的策略具有无一氧化碳气体，对环境无害，一锅多步转化，市售试剂，便宜的无任何添加剂的催化剂，宽泛的官能团耐受性和操作便利性的特点。
• PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
  申请人：——

  公开号：US20010014691A1

  公开（公告）日：2001-08-16

  Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines, including pyridyloxylalkylamines and phenoxyalkylamines. Exemplary compounds include dimethyl(2-(3-pyridyloxy)ethylamine, dimethyl(4-(3-pyridyloxy)butyl)amine, 2-(3-pyridyloxy)ethylamine, 4-(3-pyridyloxy)butylamine, methyl(3-(5-methoxy-3-pyridyloxy)propyl)amine, ethyl(3-(3-pyridyloxy)propyl)amine, methyl(2-(3-pyridyloxy)ethyl)amine, methyl(3-(6-methyl(3-pyridyloxy))propyl)amine, (3-(3-methoxyphenoxy)propyl)methylamine, (3-(5-chloro(3-pyridyloxy))-1-methylpropyl)methylamine, dimethyl(3-(3-pyridyloxy)propyl)amine, 3-(3-pyridyloxy)propylamine, methyl(4-(3-pyridyloxy)butyl)amine, 3-(5-chloro-3-pyridyloxy)propyl amine, methyl(3-(5-isopropoxy-3-pyridyloxy)propyl)amine, (3-(5-chloro(3-pyridyloxy))propyl) methylamine, methyl(3-(5-(phenylmethoxy)(3-pyridyloxy))propyl)amine, methyl(3-(2-methyl(3-pyridyloxy))propyl)amine, (methylethyl)(3-(3-pyridyloxy)propyl)amine, benzyl(3-(3-pyridyloxy)propyl)amine, cyclopropyl(3-(3-pyridyloxy)-propyl)amine, methyl(1-methyl-3-(3-pyridyloxy)propyl)amine, methyl(3-(3-nitrophenoxy)propyl)amine, 1-(3-chloropropoxy)-3-nitrobenzene, (3-(3-aminophenoxy)propyl)methylamine,dimethyl (3-(3-(methylamino)-propoxy)phenyl)amine, methyl(3-tricyclo[7.3.1.0<5,13>]tridec-2-yloxypropyl)amine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, 3-(4-piperidinyloxy)pyridine and 3-((3S)-3-pyrrolidinyloxy)pyridine.

  患有或易受中枢神经系统疾病等病症和紊乱的患者，通过向需要的患者施用芳基氧烷胺类化合物进行治疗，包括吡啶氧烷胺和苯氧烷胺。示例化合物包括二甲基(2-(3-吡啶氧基)乙基)胺，二甲基(4-(3-吡啶氧基)丁基)胺，2-(3-吡啶氧基)乙基胺，4-(3-吡啶氧基)丁基胺，甲基(3-(5-甲氧基-3-吡啶氧基)丙基)胺，乙基(3-(3-吡啶氧基)丙基)胺，甲基(2-(3-吡啶氧基)乙基)胺，甲基(3-(6-甲基(3-吡啶氧基))丙基)胺，(3-(3-甲氧基苯氧基)丙基)甲基胺，(3-(5-氯(3-吡啶氧基))-1-甲基丙基)甲基胺，二甲基(3-(3-吡啶氧基)丙基)胺，3-(3-吡啶氧基)丙基胺，甲基(4-(3-吡啶氧基)丁基)胺，3-(5-氯-3-吡啶氧基)丙基胺，甲基(3-(5-异丙氧基-3-吡啶氧基)丙基)胺，(3-(5-氯(3-吡啶氧基))丙基)甲基胺，甲基(3-(5-(苯甲氧基)(3-吡啶氧基))丙基)胺，甲基(3-(2-甲基(3-吡啶氧基))丙基)胺，(甲基乙基)(3-(3-吡啶氧基)丙基)胺，苄基(3-(3-吡啶氧基)丙基)胺，环丙基(3-(3-吡啶氧基)-丙基)胺，甲基(1-甲基-3-(3-吡啶氧基)丙基)胺，甲基(3-(3-硝基苯氧基)丙基)胺，1-(3-氯丙氧基)-3-硝基苯，(3-(3-氨基苯氧基)丙基)甲基胺，二甲基(3-(3-(甲氨基)-丙氧基)苯基)胺，甲基(3-三环七叁.壹.零<5,13>三十二氧基丙基)胺，(3-苯并三.四-壹,三-二氧杂环戊氧基丙基)甲基胺，3-(4-哌啶氧基)吡啶和3-((3S)-3-吡咯啶氧基)吡啶。
• Organic reactions in ionic liquids: Ionic liquid-promoted efficient synthesis of<i>N</i>-alkyl and<i>N</i>-arylphthalimides
  作者：Zhang-Gao Le、Zhen-Chu Chen、Yi Hu、Qin-Guo Zheng

  DOI：10.1002/jhet.5570420442

  日期：2005.5

  Phthalic anhydride reacts rapidly with Aromatic and aliphatic amines in ionic liquid [Bmim][PF6] or [Bmim][BF4] at 130 °C to give N-aryl and N-alkylphthalimides in excellent yields.

  邻苯二甲酸酐在130°C的离子液体[Bmim] [PF 6 ]或[Bmim] [BF 4 ]中与芳族和脂肪族胺迅速反应，以优异的收率得到N-芳基和N-烷基邻苯二甲酰亚胺。
• MODIFIED POLYCARBONATES HAVING IMPROVED SURFACE PROPERTIES
  申请人：Meyer Alexander

  公开号：US20110152470A1

  公开（公告）日：2011-06-23

  The present invention relates to polycarbonates comprising imide-containing aryl mono- or dihydroxy compounds as chain terminators and, respectively, monomer units, and also to compositions comprising the said polycarbonates, to their use for the production of mouldings, and to mouldings obtainable therefrom.

  本发明涉及使用含有亚酰基的芳基单或双羟基化合物作为链终止剂和单体单元的聚碳酸酯，以及包含所述聚碳酸酯的组合物，其用于生产模塑件，以及由其获得的模塑件。
• Modified polycarbonates having improved surface properties
  申请人：Meyer Alexander

  公开号：US08507635B2

  公开（公告）日：2013-08-13

  The present invention relates to polycarbonates comprising imide-containing aryl mono- or dihydroxy compounds as chain terminators and, respectively, monomer units, and also to compositions comprising the said polycarbonates, to their use for the production of mouldings, and to mouldings obtainable therefrom.

  本发明涉及以含亚酰基的芳基单醇或双醇化合物作为链终止剂和单体单元的聚碳酸酯，以及包含所述聚碳酸酯的组合物，其用于生产模塑件，以及由其获得的模塑件。