N-(4-(7-(3,4-dichlorophenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)acetamide | 1307885-47-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N-(4-(7-(3,4-dichlorophenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)acetamide
• 英文别名: N-[4-[7-(3,4-dichlorophenyl)-1,3-dimethyl-2,6-dioxopurin-8-yl]phenyl]acetamide
• CAS: 1307885-47-7
• 化学式: C₂₁H₁₇Cl₂N₅O₃
• 分子量: 458.304
• InChiKey: UTCHMTWNQVQWEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  87.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-(3,4-dichlorophenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione 、 4'-溴乙酰苯胺 在 copper(l) iodide 、 palladium diacetate 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 以41%的产率得到N-(4-(7-(3,4-dichlorophenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)acetamide
  参考文献：
  名称：

  Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution

  摘要：

  The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed a family of potent fluorescent PI3K alpha inhibitors in which part of the fluorophore was engineered to be a pharmacophore capable of inhibiting PI3K alpha. These xanthine derivatives are characterized by a donor-acceptor molecular structure, and changes in the electronic properties of the two variation points at R-1 and R-2 give rise to notable bathochromic shifts in the lambda(em), (abs) and increase the value of Phi(F). Further, we illustrated the use of E2 (PI3K alpha/IC50 = 0.068 mu M, T47D cell viability: IC50 = 0.9 mu M) to block cancer cell proliferation and to monitor its subcellular localization by fluorescence microscopy. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.03.025

文献信息

• Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution
  作者：Donghee Kim、Hyunseung Lee、Hwiseok Jun、Soon-Sun Hong、Sungwoo Hong

  DOI：10.1016/j.bmc.2011.03.025

  日期：2011.4

  The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed a family of potent fluorescent PI3K alpha inhibitors in which part of the fluorophore was engineered to be a pharmacophore capable of inhibiting PI3K alpha. These xanthine derivatives are characterized by a donor-acceptor molecular structure, and changes in the electronic properties of the two variation points at R-1 and R-2 give rise to notable bathochromic shifts in the lambda(em), (abs) and increase the value of Phi(F). Further, we illustrated the use of E2 (PI3K alpha/IC50 = 0.068 mu M, T47D cell viability: IC50 = 0.9 mu M) to block cancer cell proliferation and to monitor its subcellular localization by fluorescence microscopy. (C) 2011 Elsevier Ltd. All rights reserved.