bis-(2-methylsulfanyl-phenyl)-disulfide | 59014-88-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: bis-(2-methylsulfanyl-phenyl)-disulfide
• 英文别名: Bis-(2-methylmercapto-phenyl)-disulfid；bis(2-methylthiophenyl)disulfide；1,1'-Disulfanediylbis[2-(methylsulfanyl)benzene]；1-methylsulfanyl-2-[(2-methylsulfanylphenyl)disulfanyl]benzene
• CAS: 59014-88-9
• 化学式: C₁₄H₁₄S₄
• 分子量: 310.529
• InChiKey: WIWZJCDAZOEKJR-UHFFFAOYSA-N

物化性质

• 熔点：
  83-85 °C
• 沸点：
  399.8±27.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis-(2-methylsulfanyl-phenyl)-disulfide 在 氢氧化钾 作用下， 生成 1-丁基硫烷基-2-甲基硫烷基-苯
  参考文献：
  名称：

  Heterocyclic Vinyl Ethers. XII. The Synthesis of Arylmercaptoacetylenes and a New Cleavage Reaction of Benzo-1,4-dithiadiene^1,2

  摘要：

  DOI：

  10.1021/ja01599a065
• 作为产物：
  描述：

  1,2-苯二硫醇 在 氢氧化钾 、 sodium hydroxide 、 乙醇 作用下， 生成 bis-(2-methylsulfanyl-phenyl)-disulfide
  参考文献：
  名称：

  Heterocyclic Vinyl Ethers. XII. The Synthesis of Arylmercaptoacetylenes and a New Cleavage Reaction of Benzo-1,4-dithiadiene^1,2

  摘要：

  DOI：

  10.1021/ja01599a065

文献信息

• Methanediphosphonate derivative, its manufacturing process and its
  申请人：Toray Industries, Inc.

  公开号：US05527940A1

  公开（公告）日：1996-06-18

  The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: ##STR1## (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2 or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.

  本发明涉及一种甲烷二膦酸酯衍生物，其制造工艺和药用应用，其表示如下式：##STR1##（其中，B为氢、烷基、羟基、烷氧基或氨基，D为硫、氧、NH、烷基取代的N、CH.sub.2或SCH.sub.2，X代表烷基、具有杂原子的烷基取代基、芳基或酰基，m表示1到5的整数，R.sup.1、R.sup.2、R.sup.3和R.sup.4分别代表氢、具有1到7个碳原子的烷基或药学上允许的阳离子）。本发明的化合物具有优异的IL-1抑制作用、抗氧化作用和抑制骨吸收作用，并可用作抗炎药、抗风湿药、骨代谢疾病药、自身免疫疾病药、骨质疏松症药等。
• Cyclic derivatives as modulators of chemokine receptor activity
  申请人：——

  公开号：US20030216434A1

  公开（公告）日：2003-11-20

  The present application describes modulators of MCP-1 of formula (I): 1 or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ transplantation, and cancer.

  本申请描述了公式（I）的MCP-1调节剂或其药用盐形式，用于预防风湿性关节炎、多发性硬化症、动脉粥样硬化、哮喘、再狭窄、器官移植和癌症。
• Cyclic derivatives as modulators of chemokine receptors activity
  申请人：Cherney J. Robert

  公开号：US20060135503A1

  公开（公告）日：2006-06-22

  The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ transplantation, and cancer.

  本申请描述了MCP-1调节剂的化学式(I)或其药学上可接受的盐形式，可用于预防类风湿性关节炎、多发性硬化症、动脉粥样硬化、哮喘、再狭窄、器官移植和癌症。
• METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0594857A1

  公开（公告）日：1994-05-04

  A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH₂ or SCH₂; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R¹, R², R³ and R⁴ represent each independently hydrogen, C₁ to C₇, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth.

  一种由式(I)或(II)代表的甲烷二膦酸衍生物、制备该衍生物的工艺及其医药用途，其中 B 代表氢、烷基、羟基、烷氧基或氨基；D 代表硫、氧、NH、烷基取代的氮、CH₂或 SCH₂；X 代表可被杂原子、芳基或酰基取代的烷基；m 代表 1 至 5 的整数；以及 R¹、R²、R³ 和 R⁴ 各自独立地代表氢、C₁ 至 C₇、烷基或药理学上可接受的阳离子。该化合物具有优异的抑制 IL-1、抗氧化活性和抑制骨吸收的作用，可用于治疗炎症、风湿病、骨代谢紊乱、自身免疫性疾病、骨质疏松症等。
• Electrochemical transformation of diazonium salts into diaryl disulfides
  作者：Fructuoso Barba、Fernando Ranz、Belen Batanero

  DOI：10.1016/j.tetlet.2009.09.102

  日期：2009.12

  Electrolyses of aryldiazonium tetrafluoroborates in CS(2)/EtOH and Bu(4)NClO(4), as the solvent-supporting electrolyte system, led to the Corresponding diaryl disulfides in good yields. (C) 2009 Elsevier Ltd. All rights reserved.