O-carboxymethyl-lactic acid | 13330-90-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-carboxymethyl-lactic acid
• 英文别名: O-Carboxymethyl-milchsaeure；Methyldiglykolsaeure；Carboxymethylaether-milchsaeure；2-Carboxymethoxy-propionsaeure；2--propionsaeure；α-Methyl-diglykolsaeure；3-Oxapentanedioic acid, 2-methyl-；2-(carboxymethoxy)propanoic acid
• CAS: 13330-90-0
• 化学式: C₅H₈O₅
• mdl: MFCD19228426
• 分子量: 148.116
• InChiKey: SZMWJECJLNOCKO-UHFFFAOYSA-N

物化性质

• 熔点：
  30 °C
• 沸点：
  410.9±20.0 °C(Predicted)
• 密度：
  1.383±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  O-carboxymethyl-lactic acid 生成 水
  参考文献：
  名称：

  Jungfleisch; Godchot, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1907, vol. 145, p. 71

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基二甘醇酸二酰胺 在 sodium hydroxide 作用下， 生成 O-carboxymethyl-lactic acid
  参考文献：
  名称：

  Godchot; Vieles, Bulletin de la Societe Chimique de France, 1937, vol. <5>4, p. 938

  摘要：

  DOI：

文献信息

• Preparation of Diglycolamides via Schotten–Baumann Approach and Direct Amidation of Esters
  作者：Willem Verboom、Andrea Leoncini、Jurriaan Huskens

  DOI：10.1055/s-0035-1561495

  日期：——

  Diglycolyl chlorides, commercially available or obtained from the corresponding dicarboxylic acids, have been converted into the corresponding diamides by reaction with a wide range of amines in an organic-aqueous biphasic system (Schotten–Baumann approach) in high yields. Treatment with poly(4-styrenesulfonic acid) afforded the pure compounds. Substituted diglycolyl diesters, obtained by coupling

  通过在有机-水双相体系（Schotten-Baumann 方法）中与多种胺反应，可以将二甘醇氯化物（市售的或从相应的二羧酸获得）转化为相应的二酰胺。用聚(4-苯乙烯磺酸)处理得到纯化合物。通过偶联商业单酯获得的取代的二甘醇二酯在作为催化剂的三氯化铝存在下以良好的产率直接转化为相应的二酰胺。
• Solladie-Cavallo,A.; Vieles,P., Bulletin de la Societe Chimique de France, 1967, p. 517 - 523
  作者：Solladie-Cavallo,A.、Vieles,P.

  DOI：——

  日期：——
• Synthesis and Am/Eu extraction of novel TODGA derivatives
  作者：Mudassir Iqbal、Jurriaan Huskens、Willem Verboom、Michal Sypula、Giuseppe Modolo

  DOI：10.1080/10610278.2010.506553

  日期：2010.11.1

  Various ligands with structural modifications of the N,N,N',N'-tetraoctyl-3-oxapentanediamide (TODGA) skeleton were synthesised in good yields. These modifications include (1) the increase in chain length from one carbon to two carbons between the central ether oxygen atom and the amide moieties, (2) the addition of substituents on the carbon between the central oxygen atom and the amide moieties on one and both sides of the central oxygen, (3) the replacement of the central oxygen by a (substituted) nitrogen atom and (4) synthesis of a rigidified glycolamide. The effect of the structural modifications on their extraction behaviours toward Am(III) and Eu(III) at various nitric acid concentrations was studied. In most of the cases, the extraction does not exceed that of TODGA in the entire acidity range of 0.001-4mol/l HNO3. The extraction behaviour of monomethyl-TODGA derivative 10a resembles that of TODGA at high nitric acid concentrations. However, at lower acidities, its D values are much lower, which is beneficial for possible back-extraction steps. The aza-tripodal ligands 18a,b show reverse extraction properties compared to TODGA as far as the pH influence is concerned: at pH 2, the DAm values are 49.9 and 3.1, the DEu values are 5.9 and 0.2, and the SAm/Eu values are 8 and 11, respectively.
• Jungfleisch; Godchot, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1907, vol. 145, p. 71
  作者：Jungfleisch、Godchot

  DOI：——

  日期：——
• Godchot; Vieles, Bulletin de la Societe Chimique de France, 1937, vol. <5>4, p. 938
  作者：Godchot、Vieles

  DOI：——

  日期：——