1-[4-(Bromomethyl)phenoxy]-2,4-dichlorobenzene | 1048358-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-(Bromomethyl)phenoxy]-2,4-dichlorobenzene
• 英文别名: 1-[4-(bromomethyl)phenoxy]-2,4-dichlorobenzene
• CAS: 1048358-85-5
• 化学式: C₁₃H₉BrCl₂O
• 分子量: 332.024
• InChiKey: DCEQFLGZCHGION-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲酰乙内脲 、 1-[4-(Bromomethyl)phenoxy]-2,4-dichlorobenzene 在 六甲基磷酰三胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 5-[[4-(2,4-Dichlorophenoxy)phenyl]methyl]-1-methylimidazolidine-2,4-dione
  参考文献：
  名称：

  Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

  摘要：

  Systematic structure-activity relationship (SAR) studies of a screening lead led to the discovery of a series of thiazolidinediones (TZDs) as potent GPR40 agonists. Among them, compound C demonstrated an acute mechanism-based glucose-lowering in an intraperitoneal glucose tolerance test (IPGTT) in lean mice, while no effects were observed in GPR40 knock-out mice. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.052

文献信息

• Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists
  作者：Changyou Zhou、Cheng Tang、Eric Chang、Min Ge、Songnian Lin、Eric Cline、Carina P. Tan、Yue Feng、Yun-Ping Zhou、George J. Eiermann、Aleksandr Petrov、Gino Salituro、Peter Meinke、Ralph Mosley、Taro E. Akiyama、Monica Einstein、Sanjeev Kumar、Joel Berger、Andrew D. Howard、Nancy Thornberry、Sander G. Mills、Lihu Yang

  DOI：10.1016/j.bmcl.2009.10.052

  日期：2010.2

  Systematic structure-activity relationship (SAR) studies of a screening lead led to the discovery of a series of thiazolidinediones (TZDs) as potent GPR40 agonists. Among them, compound C demonstrated an acute mechanism-based glucose-lowering in an intraperitoneal glucose tolerance test (IPGTT) in lean mice, while no effects were observed in GPR40 knock-out mice. (C) 2010 Elsevier Ltd. All rights reserved.