1,3,5-Trimethyladamantyl-7-carboxylic acid chloride | 50741-88-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 1,3,5-Trimethyladamantyl-7-carboxylic acid chloride
• 英文别名: 3,5,7-trimethyl-1-adamantanecarbonyl chloride；3,5,7-trimethyladamantane-1-carbonyl chloride；3,5,7-Trimethyladamantoyl Chloride
• CAS: 50741-88-3
• 化学式: C₁₄H₂₁ClO
• 分子量: 240.773
• InChiKey: STZWYHYHQQJKOL-UHFFFAOYSA-N

物化性质

• 沸点：
  269.6±9.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,3,5-Trimethyladamantyl-7-carboxylic acid chloride 在 氨 作用下， 生成 3,5,7-Trimethyl-adamantane-1-carboxylic acid amide
  参考文献：
  名称：

  药物中的金刚烷基。IV。3,5,7-三甲基金刚烷-1-羧酰胺和相关药物的镇静作用。

  摘要：

  DOI：

  10.1021/jm00316a018
• 作为产物：
  描述：

  3,5,7-trimethyltricyclo[3.3.1.13,7]decan-1-ol 在 氯化亚砜 、 硫酸 作用下， 反应 2.0h， 生成 1,3,5-Trimethyladamantyl-7-carboxylic acid chloride
  参考文献：
  名称：

  Synthesis and biological activity of hydroxamic acids with a skeleton fragment and their complexes with Cu(2+) and Fe(3+)

  摘要：

  DOI：

  10.1007/bf01151183

文献信息

• Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
  申请人：Kelly G. Michael

  公开号：US20060217448A1

  公开（公告）日：2006-09-28

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  公开了具有以下公式代表的Bicycloheteroaryl化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如疼痛、炎症、创伤性损伤等。
• [EN] AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS<br/>[FR] MODULATEURS DE LXR À BASE D'AMINE OU DE (THIO) AMIDE
  申请人：PHENEX FXR GMBH

  公开号：WO2019016269A1

  公开（公告）日：2019-01-24

  The present invention relates to derivatives of formula (I) which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR.

  本发明涉及公式（I）的衍生物，其结合到肝X受体（LXRα和/或LXRβ），并且作为LXR的拮抗剂。
• Antitumor and immunosuppresive 4-carbamoyl imidazolium-5-olate
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04332806A1

  公开（公告）日：1982-06-01

  There are provided compounds of the formula: ##STR1## wherein R is an adamantoyl group substituted with a lower alkyl group, a lower alkoxy group, a hydroxy group, a lower alkanoyloxy group, an aroyloxy group, a halogen atom, an acetamido group, a nitro group, an azide group, a trifluoromethyl group or a phenyl group which may be substituted with a nitro group, a halogen atom, a lower alkyl group or a lower alkoxy group and a process producing them. These compounds are useful as antitumor agents and immunosuppressants.

  提供了以下化合物的化学式：##STR1## 其中R是一个由低烷基基团、低烷氧基团、羟基、低烷酰氧基团、芳酰氧基团、卤素原子、乙酰胺基团、硝基基团、叠氮基团、三氟甲基基团或苯基取代的金刚烷基团，该苯基可能被硝基基团、卤素原子、低烷基基团或低烷氧基团取代，以及生产这些化合物的过程。这些化合物可用作抗肿瘤剂和免疫抑制剂。
• [EN] ANTI-INFLAMMATORY AGENTS<br/>[FR] AGENTS ANTI-INFLAMMATOIRES
  申请人：UNIV CAMBRIDGE TECH

  公开号：WO2006016152A1

  公开（公告）日：2006-02-16

  The invention provides compounds, compositions and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, which are 3-aminocaprolactam derivatives, for the preparation of a medicament intended to treat an inflammatory disorder wherein X is -CO-Y-(R1)n or SO2-Y-(R1)n; and Y is 0 cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or is 0 cycloalkenyl or polycycloalkenyl group.

  本发明提供了通式（I）的化合物、组合物及其药学上可接受的盐的用途，其中X为-CO-Y-(R1)n或SO2-Y-(R1)n；Y为0环烷基或多环烷基（例如，金刚烷基，金刚烷甲基，双环辛基，环己基，环丙基）；或为0环烯基或多环烯基。这些化合物是3-氨基己内酯衍生物，用于制备用于治疗炎症性疾病的药物。
• Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
  申请人：Kelly G Michael

  公开号：US20080039478A1

  公开（公告）日：2008-02-14

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  本文披露了一种具有以下公式表示的Bicycloheteroaryl化合物：这些化合物可以制备为药物组成物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛，炎症，创伤性损伤等。