2-氨基-1-(4-氟苯基)-乙醇盐酸盐 | 403-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氨基-1-(4-氟苯基)-乙醇盐酸盐
• 中文别名: 2-羟基-2-(4-氟苯基)乙胺盐酸盐
• 英文名称: 2-amino-1-(4-fluorophenyl)ethan-1-ol hydrochloride
• 英文别名: 2-amino-1-(4-fluoro-phenyl)-ethanol; hydrochloride；2-Amino-1-(4-fluor-phenyl)-aethanol; Hydrochlorid；2-amino-1-(4-fluorophenyl)ethanol;hydron;chloride
• CAS: 403-28-1
• 化学式: C₈H₁₀FNO*ClH
• 分子量: 191.633
• InChiKey: PNSJHCBYUNINNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.24
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  2-氨基-1-(4-氟苯基)-乙醇盐酸盐 在 硼烷四氢呋喃络合物 、 potassium tert-butylate 、 三乙胺 作用下， 以 四氢呋喃 、 乙腈 、 叔丁醇 为溶剂， 反应 37.0h， 生成 tert-butyl 3-(4-((2-(4-fluorophenyl)morpholine)-4-sulfonamido)-3-(methoxycarbonyl)phenoxy)azetidine-1-carboxylate
  参考文献：
  名称：

  [EN] INHIBITORS OF MSBA AS ANTIBIOTICS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
  [FR] INHIBITEURS DE MSBA EN TANT QU'ANTIBIOTIQUES, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS

  摘要：

  The present disclosure is directed to certain functionalized dual substituted arene derivatives (e.g., arenesulfonamide, arenesulfamide, areneoxalamide and areneamide derivatives) of Formula I: and pharmaceutically acceptable salts thereof, wherein X1, X2, Y, Z, G, R1, R2, R3, R4, and R5are as defined herein, which are potent inhibitors of MsbA and may be useful in the treatment of infections caused by any multi-drug resistant (MDR) Gram-negative bacteria. The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of infections in which MsbA is involved.

  公开号：

  WO2023224893A1

文献信息

• Amido thiadiazole derivatives as NADPH oxidase inhibitors
  申请人：GENKYOTEX SUISSE SA

  公开号：US10130619B2

  公开（公告）日：2018-11-20

  The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的氨基噻唑衍生物、其药物组合物及其用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH 氧化酶）有关的紊乱或病症的用途。
• AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：GENKYOTEX SUISSE SA

  公开号：US20170348296A1

  公开（公告）日：2017-12-07

  The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).