2-氨基-1-(4-羟基苯基)-1-丙醇盐酸盐 | 13062-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氨基-1-(4-羟基苯基)-1-丙醇盐酸盐
• 英文名称: α-(1-aminoethyl)-4-hydroxybenzyl alcohol hydrochloride
• 英文别名: alpha-(1-Aminoethyl)-4-hydroxybenzyl alcohol hydrochloride；4-(2-amino-1-hydroxypropyl)phenol;hydrochloride
• CAS: 13062-82-3
• 化学式: C₉H₁₃NO₂*ClH
• mdl: MFCD00013020
• 分子量: 203.669
• InChiKey: AYEOOGDUDIHXQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.05
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  68.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2923900090

反应信息

• 作为反应物：
  描述：

  2-氨基-1-(4-羟基苯基)-1-丙醇盐酸盐 在 盐酸 、 碳酸氢钠 作用下， 以 四氢呋喃 、 甲醚 为溶剂， 生成 N-[2,2-Bis-(4-hydroxyphenyl)-1-methylethyl]benzamide
  参考文献：
  名称：

  Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

  摘要：

  Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00404-7

文献信息

• Bicyclic cyclohexylamines and their use as nmda receptor antagonists
  申请人：——

  公开号：US20030236252A1

  公开（公告）日：2003-12-25

  Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's specification. disease. The substituents are defined in the specification. 1

  描述了公式（I）的自行车替代环己胺及其药用盐。这些化合物是NMDA受体通道复合物的拮抗剂，可用于治疗脑血管疾病，例如脑缺血、心脏骤停、中风和帕金森病。这些取代基在规范中有定义。
• Substituted phenols as novel calcium channel blockers
  申请人：Warner-Lambert Company

  公开号：US06124280A1

  公开（公告）日：2000-09-26

  The present invention relates to novel substituted phenols and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing the compounds are also includes.

  本发明涉及新型取代酚及其衍生物，用于治疗神经系统疾病。制备这些化合物的方法，制备中间体以及含有这些化合物的药物组合物也包括在内。
• Synthesis and evaluation of uterine relaxant activity for a novel series of substituted p-hydroxyphenylethanolamines
  作者：C.L. Viswanathan、A.S. Chaudhari

  DOI：10.1016/j.bmc.2006.06.006

  日期：2006.10

  Novel racemic 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl]aminopropan-1-ol hydrochlorides (9a-h) were synthesized by condensing racemic 1-(p-hydroxyphenyl)-2-aminopropan-1-ol hydrochloride (6) with substituted aryloxymethyloxiranes (8a-h) in DMF in presence of anhydrous potassium carbonate and then reacting with dry hydrogen chloride gas. They were evaluated for uterine relaxant

  通过缩合外消旋1-（对羟基苯基）合成新型外消旋1-（4-羟基苯基）-2- [3-（取代苯氧基）-2-羟基-1-丙基]氨基丙烷-1-醇盐酸盐（9a-h）。 ）-2-氨基丙-1-醇盐酸盐（6）在无水碳酸钾存在下于DMF中与取代的芳氧基甲基环氧乙烷（8a-h）混合，然后与干燥的氯化氢气体反应。对离体大鼠子宫的体外子宫松弛活性和妊娠大鼠体内的子宫松弛活性进行了评估。使用大鼠子宫组织匀浆通过cAMP [3H]分析研究了它们的cAMP释放潜能，并评估了狗的心脏刺激潜能。所有化合物在体外均表现出有效的子宫松弛活性，并显着延迟了妊娠大鼠的分娩。除9b和9c外，它们的cAMP释放潜能均高于盐酸异苏比林。最后，与盐酸异苏必林相比，这些化合物的心脏刺激潜力微不足道。
• Antimitotic agents. Chiral isomers of ethyl 5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7-ylcarbamate
  作者：Carroll Temple、Gregory A. Rener

  DOI：10.1021/jm00084a003

  日期：1992.3

  Metabolism studies with ethyl [5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7 - yl]carbamate (1) in mice were reported previously to give a hydroxylated metabolite, which was methylated to give a methoxy derivative. The metabolite and its derivatives were considered to be 4-(substituted)phenyl compounds, which have been confirmed by the synthesis of the [1,2-dihydro-3-(4-hydroxyphenyl)-

  先前曾有报道称[5-氨基-1,2-二氢-2-甲基-3-苯基吡啶并[3,4-b]吡嗪-7-基]氨基甲酸酯乙酯在小鼠中的代谢研究产生羟基化代谢物，甲基化得到甲氧基衍生物。代谢物及其衍生物被认为是4-（取代）苯基化合物，已通过[1,2-二氢-3-（4-羟苯基）-和[1,2-二氢-3]的合成得到证实。 -（4-甲氧基苯基）吡啶并[3，4-b]-吡嗪-7-基]氨基甲酸酯（17和16）。17的S和R异构体在几种生物系统中均具有活性，但是S异构体比R异构体更有效。17的S和R异构体之间的活性差异与1的S和R异构体所观察到的相似。
• Synthesis and uses of synephrine derivatives
  申请人：Chen Jian

  公开号：US20050250944A1

  公开（公告）日：2005-11-10

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β 3 -adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.

  本发明公开了一种新型合成橙皮碱、其衍生物和上述衍生物的盐，包括它们的中间体。橙皮碱的氮原子的一个或多个取代基被修改以产生衍生物。橙皮碱衍生物及其盐可用于治疗受β3-肾上腺素受体调节的动物的疾病、症状或紊乱。它们通常用作脂肪分解剂和/或减肥剂。

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