1-methyl-4-methoxy-1H-imidazo<4,5-c>pyridine | 120759-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 1-methyl-4-methoxy-1H-imidazo<4,5-c>pyridine
• 英文别名: 4-Methoxy-1-methylimidazo[4,5-c]pyridine
• CAS: 120759-65-1
• 化学式: C₈H₉N₃O
• 分子量: 163.179
• InChiKey: ZKTHLGMSFRVDAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-methyl-4-methoxy-1H-imidazo<4,5-c>pyridine 在 sulfur 作用下， 反应 0.5h， 以97%的产率得到4-Methoxy-1-methyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-thione
  参考文献：
  名称：

  Thionation of imidazopyridines

  摘要：

  DOI：

  10.1007/bf00475602
• 作为产物：
  描述：

  4-氯-1-甲基-1H-咪唑[4,5-c]吡啶 、 sodium methylate 以 甲醇 为溶剂， 反应 2.0h， 以81%的产率得到1-methyl-4-methoxy-1H-imidazo<4,5-c>pyridine
  参考文献：
  名称：

  Thionation of imidazopyridines

  摘要：

  DOI：

  10.1007/bf00475602

文献信息

• [EN] NEW MACROLIDES AND THEIR USE<br/>[FR] NOUVEAUX MACROLIDES ET LEUR UTILISATION
  申请人：BASILEA PHARMACEUTICA AG

  公开号：WO2009106419A1

  公开（公告）日：2009-09-03

  The invention relates to macrolide compounds of formula (I),the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with anti-inflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.

  本发明涉及公式(I)的大环内酯化合物，以及所述化合物作为药物的应用，特别是用于治疗或预防炎性和过敏性疾病，包含所述化合物的药物组合物，以及它们的制备过程。本发明特别涉及主要通过抑制磷酸二酯酶4（PDE4）介导抗炎活性的大环内酯化合物，这使得它们可用于治疗和/或预防诸如慢性阻塞性肺病（COPD）、哮喘、类风湿性关节炎、特应性皮炎、炎症性肠病或增殖性疾病，例如癌症等炎性和过敏性疾病。
• YUTILOV, YU. M.;SVERTILOVA, I. A., XIMIYA GETEROTSIKL. SOED.,(1988) N 6, 799-804
  作者：YUTILOV, YU. M.、SVERTILOVA, I. A.

  DOI：——

  日期：——
• MACROLIDES AND USES OF MACROLIDES
  申请人：Kellenberger Johannes Laurenz

  公开号：US20110021449A1

  公开（公告）日：2011-01-27

  Macrolides of Formula (I) or (I-A): and wherein the residues R1, R2, R3, R4, R12, R13 and R14 have certain meanings defined in this application are useful for treating or preventing inflammatory or allergic diseases or. cancer in animals and humans.
• MACROLIDES AND THEIR USE
  申请人：Kellenberger Johannes Laurenz

  公开号：US20110053876A1

  公开（公告）日：2011-03-03

  The invention relates to macrolide compounds of formula (I), the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with anti-inflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.
• NEW MACROLIDES AND THEIR USE
  申请人：Kellenberger Johannes Laurenz

  公开号：US20120277174A1

  公开（公告）日：2012-11-01

  The invention relates to macrolide compounds of formula (I), the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with antiinflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.