5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester | 72180-34-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
• 英文别名: 1-Benzyl 2-methyl 5-hydroxypiperidine-1,2-dicarboxylate；1-O-benzyl 2-O-methyl 5-hydroxypiperidine-1,2-dicarboxylate
• CAS: 72180-34-8
• 化学式: C₁₅H₁₉NO₅
• 分子量: 293.32
• InChiKey: NLHXFVLVIIBQOM-UHFFFAOYSA-N

物化性质

• 沸点：
  436.1±45.0 °C(Predicted)
• 密度：
  1.272±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Method for Producing cis-5-hydroxy-2-piperidinecarboxylic Acid Derivative, and Method for Purifying cis-5-hydroxy-2-piperidinecarboxylic Acid
  申请人：API CORPORATION

  公开号：US20150239906A1

  公开（公告）日：2015-08-27

  The present invention aims to provide a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid with high purity, and a method for producing its derivative. The present invention provides a method for producing a cis-5-hydroxy-2-piperidinecarboxylic acid derivative, which method comprises a step of converting cis-5-hydroxy-2-piperidinecarboxylic acid into a compound(s) of Formula (1) and/or Formula (2) (wherein R 1 represents a protective group for an amino group, and R2 represents a C 1 -C 6 alkyl group), and a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid.

  本发明旨在提供一种高纯度纯化顺式-5-羟基-2-哌啶羧酸的方法，以及其衍生物的生产方法。本发明提供了一种生产顺式-5-羟基-2-哌啶羧酸衍生物的方法，该方法包括将顺式-5-羟基-2-哌啶羧酸转化为式（1）和/或式（2）化合物的步骤（其中R1代表氨基的保护基，R2代表C1-C6烷基），以及一种纯化顺式-5-羟基-2-哌啶羧酸的方法。
• Piperidylthiocarbapenem derivatives
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0411636A2

  公开（公告）日：1991-02-06

  A compound represented by the general formula (I): wherein R¹ is a hydrogen atom or a methyl group; R² and R³, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or taken together with the adjacent nitrogen atom, jointly represent a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group, a 4-lower alkylpiperazinyl group, a morpholino group and a thiomorpholino group; and A is a single bond, a lower alkylene group, a lower alkenylene group or a lower alkynylene group; or a pharmaceutically acceptable salt or ester thereof. The compound of the general formula (I) and their salts or esters exhibit excellent antibacterial activity.

  由通式(I)代表的化合物： 其中 R¹是氢原子或甲基；R²和 R³可以相同或不同，各自代表氢原子或低级烷基，或与相邻的氮原子一起共同代表选自氮丙啶基、氮杂环丁基、吡咯烷基、哌啶基、哌嗪基、4-低级烷基哌嗪基、吗啉基和硫代吗啉基组成的杂环基团；和 A 是单键、低级烯基、低级炔基或低级炔基；或其药学上可接受的盐或酯。 通式（I）的化合物及其盐或酯具有优异的抗菌活性。
• METHOD FOR PRODUCING cis-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID DERIVATIVE, AND METHOD FOR PURIFYING cis-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID
  申请人：API Corporation

  公开号：EP2889288B1

  公开（公告）日：2018-07-25
• US9981984B2
  申请人：——

  公开号：US9981984B2

  公开（公告）日：2018-05-29