3-(4-chloro-phenoxy)-propionaldehyde | 138977-77-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-chloro-phenoxy)-propionaldehyde
• 英文别名: 3-(4-Chlor-phenoxy)-propionaldehyd；2-(4-chloro-phenoxy)propionaldehyde；3-(4-Chlorophenoxy) propanal；3-(4-Chlorophenoxy)-propanal；3-(4-Chlorophenoxy)propanal
• CAS: 138977-77-2
• 化学式: C₉H₉ClO₂
• 分子量: 184.622
• InChiKey: RTHYQTNEJIKYCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二甲基乙烯酮 、 3-(4-chloro-phenoxy)-propionaldehyde 在 zinc(II) chloride 作用下， 以 乙酸乙酯 为溶剂， 以0.91 g (89%)的产率得到5-(4-Chlorophenoxy)-2,2-dimethyl-3-hydroxypentanoic Acid β-lactone
  参考文献：
  名称：

  Derivatives and preparation of 2,2-dimethyl-5-substituted

  摘要：

  制备了式(I)的2,2-二甲基-5-取代苯氧基-戊酸的新型3-取代衍生物。这些化合物是从2,2-二甲基-5-取代苯氧基-3-羟基-戊酸-β-内酯（式II）制备的。β-内酯是通过将相关的苯氧基丙醛与二甲基乙烯酮缩合制备的。

  公开号：

  US05412112A1
• 作为产物：
  描述：

  对氯苯酚 、 丙烯醛 生成 3-(4-chloro-phenoxy)-propionaldehyde
  参考文献：
  名称：

  Beta-aryloxy aldehydes and preparation of the same

  摘要：

  公开号：

  US02500582A1

文献信息

• [EN] SUBSTITUTED GLYCINE DERIVATIVES FOR USE AS MEDICAMENTS<br/>[FR] DERIVES DE GLYCINE SUBSTITUES SERVANT DE MEDICAMENTS
  申请人：PFIZER LTD

  公开号：WO2004016583A1

  公开（公告）日：2004-02-26

  The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included. Formula (I) wherein R' is hydroxycarbonyl, a carboxylic acid biostere or prodrug thereof; R3, R3a, R2 and R2a are independently selected from H, C1-C6 alkyl, and Cl-C6 alkoxy Cl-C6 alkyl.

  公式(I)的化合物是取代甘氨酸衍生物，可用于治疗癫痫、晕厥发作、运动减少、颅脑疾病、神经退行性疾病、抑郁症、焦虑症、恐慌症、疼痛、关节炎、神经病理学疾病、睡眠障碍、内脏疼痛疾病和胃肠疾病。包括用于制备最终产品和在过程中有用的中间体的方法。还包含含有一种或多种化合物的药物组合物。公式(I)中，R'是羟碳酰基，羧酸的生物立体异构体或前药；R3、R3a、R2和R2a独立地选自H、C1-C6烷基和Cl-C6烷氧基Cl-C6烷基。
• 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
  申请人：Tsubouchi Hidetsugu

  公开号：US20060094767A1

  公开（公告）日：2006-05-04

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group —OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and —(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.

  本发明提供了一种2,3-二氢-6-硝基咪唑并[2,1-b]噁唑化合物，其通式如下：其中，R1代表氢原子或C1-C6烷基，n代表0到6的整数，R2代表—OR3或类似的基团，R3代表氢原子、C1-C6烷基或类似的基团，或者R1和—(CH2)nR2可以通过相邻的碳原子通过氮原子结合在一起形成一个螺环，其通式为（H）：其中，R41为氢、C1-C6烷基或类似的基团。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型酸性快速细菌具有优异的杀菌作用。
• Novel antiviral compounds
  申请人：G.D. Searle & Co.

  公开号：EP0494850A2

  公开（公告）日：1992-07-15

  O-acylated derivatives of 1,5-dideoxy-1,5-imino-D-glucitol are disclosed that contain an N-alkyl or N-aroyl radical in which from one to four of the free hydroxyl groups are O-acylated with carboxylic alkanoyl radicals selected from the group consisting of w,w,w-trifluoro alkanoyl having from three to eight carbon atoms, carboxylic cycloalkanoyl groups having from four to eight carbon atoms and carboxylic acyclic alkanoyl groups having from two to ten carbon atoms, wherein the N-aroyl radical is selected from the group consisting of p-decylbenzoyl, 3-(p-chlorophenoxy)-propanoyl, 2-(acetyloxy)benzoyl, [1,1' -biphenyl]-4-ylcarbonyl, 2-thiopheneacetyl, trans-3-furanacryloyl, 3-methoxyphenylacetyl and 3-(trifluoromethyl)benzoyl, and wherein the N-alkyl contains from one to fourteen carbon atoms, provided that when N-alkyl contains from one to five carbon atoms the O-acylated groups are w,w,w-trifluoro alkanoyl or carboxylic cycloalkanoyl.

  本发明公开了 1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的 O-酰化衍生物，该衍生物含有 N-烷基或 N-芳酰基，其中 1 至 4 个游离羟基与选自以下组别的羧基烷酰基 O-酰化：具有 3 至 8 个碳原子的 w,w-三氟烷酰基、具有 4 至 8 个碳原子的羧基环烷酰基和羧基无环烷酰基、w，w-三氟烷氧基（具有 3 至 8 个碳原子）、环烷氧基（具有 4 至 8 个碳原子）和无环烷氧基（具有 2 至 10 个碳原子）组成的组、其中，N-芳酰基选自由对-癸基苯甲酰基、3-（对氯苯氧基）-丙酰基、2-（乙酰氧基）苯甲酰基、[1,1'-联苯]-4-基羰基、2-噻吩乙酰基、反式-3-呋喃丙烯酰基、3-甲氧基苯乙酰基和 3-（三氟甲基）苯甲酰基组成的组、其中 N-烷基含有 1 至 14 个碳原子，但当 N-烷基含有 1 至 5 个碳原子时，O-酰化基团为 w,w,w-三氟烷酰基或羧基环烷酰基。
• 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1555267A1

  公开（公告）日：2005-07-20

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group -OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and -(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and a typical acid-fast bacteria.

  本发明提供了由以下通式代表的 2，3-二氢-6-硝基咪唑并[2，1-b]恶唑化合物： 其中R1代表氢原子或C1-C6烷基，n代表0至6的整数，R2代表基团-OR3或类似基团，R3代表氢原子、C1-C6烷基或类似基团，或者R1和-(CH2)nR2可以通过氮原子与相邻的碳原子相互结合，从而形成通式(H)代表的螺环： 其中 R41 为氢、C1-C6 烷基或类似基团。本化合物对结核分枝杆菌、多重耐药结核分枝杆菌和典型的耐酸细菌有很好的杀菌作用。
• 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2570418A2

  公开（公告）日：2013-03-20

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group -OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and -(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

  本发明提供了一种由以下通式表示的 2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物： 其中R1代表氢原子或C1-C6烷基，n代表0至6的整数，R2代表基团-OR3或类似基团，R3代表氢原子、C1-C6烷基或类似基团，或者R1和-(CH2)nR2可以通过氮原子与相邻的碳原子相互结合，从而形成通式(H)代表的螺环： 其中 R41 为氢、C1-C6 烷基或类似基团。本化合物对结核分枝杆菌、多重耐药结核分枝杆菌和非典型耐酸菌有很好的杀菌作用。