2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate | 115914-74-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate
• 英文别名: 3,4-Epoxybutyl tosylate
• CAS: 115914-74-4
• 化学式: C₁₁H₁₄O₄S
• 分子量: 242.296
• InChiKey: OOCUYWYPDMKZOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  381.4±15.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate 在 吡啶 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 14.0h， 生成 3-pivaloyloxy-1-(phenylthio)-1-(trimethylsilyl)cyclopentane
  参考文献：
  名称：

  Variation of the C1 component in the silicon-induced domino synthesis of cyclopentanes

  摘要：

  The reaction of mono- or bissilylated thioanisole derivatives 2b-e with 3,4-epoxybutyl tosylate (3) affords the cyclopentanols 6a-c. Migratory aptitudes of two different silyl groups in the Brook 1,4-rearrangement is examined starting from 2d, e giving the order SiMe2Ph > SiMe3 > SiMePh2. The relative configuration of the resulting 1,3-functionalized cyclopentanes is established by NOE experiments after derivatization of the alcohol to the corresponding pivalates 7a-c. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00697-8
• 作为产物：
  描述：

  丁-3-烯-1-醇,4-甲基苯磺酸 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以75%的产率得到2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  硅诱导的多米诺反应合成功能化的环戊烷，环己烷和环庚烷

  摘要：

  1,3-官能化的环戊烷，-己烷和-庚烷是通过将锂化的甲硅烷基二硫缩醛7加到环氧同烯丙基甲苯磺酸酯4-6中获得的。该反应涉及环氧化物环的级联，布鲁克1,4-重排和甲苯磺酸酯的取代。该方法特别适合于制备环戊烷，而形成环己烷和庚烷的产率仅高达49％。对映体纯的环氧化物的使用提供了光学活性的环戊烷（S）-10b，d，11a以及氧杂环丁烷（S）-14a，b。二硫缩醛官能团的水解导致相应的酮12，环氧化物的环化作用24b给出了一个稠合环戊烷26，其构造是由二硝基苯甲酸盐的X射线结构分析确定27。环氧化物29b的使用提供了带芳基的四氢呋喃30。

  DOI：

  10.1002/jlac.199619961115

文献信息

• METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS
  申请人：Papamichelakis Maria

  公开号：US20090156826A1

  公开（公告）日：2009-06-18

  The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.

  本发明涉及制备式I的羟基取代芳基磺酰胺衍生物或其药学上可接受的盐、立体异构体或互变异构体的过程，其中所述衍生物是单胺再摄取抑制剂，其组成变量如本文所定义。
• HYDROXY-SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE
  申请人：McComas Casey Cameron

  公开号：US20080194654A1

  公开（公告）日：2008-08-14

  The present invention is directed to hydroxy-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

  本发明涉及式I的羟基取代芳基磺酰胺衍生物：或其药学上可接受的盐、立体异构体或互变异构体，它们是单胺再摄取抑制剂，包含这些衍生物的组合物，以及它们用于预防和治疗包括血管运动症状、性功能障碍、胃肠障碍和泌尿系障碍、抑郁症、内源性行为障碍、认知障碍、糖尿病神经病变、疼痛和其他疾病或障碍的方法。
• Amine condensation polymers as phosphate sequestrants
  申请人：Huval C. Chad

  公开号：US20080085259A1

  公开（公告）日：2008-04-10

  Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH 2 CH 2 — group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.

  本发明公开了一种聚合物或其生理上可接受的盐。该聚合物包括聚合的多功能胺单体。该胺单体包括至少两个胺基和至少两个通过—CH2CH2—基团连接的非环氮原子，但不包括乙二胺或二乙烯三胺。所公开的聚合物可用于结合需要此类治疗的受体中的阴离子。
• Amine Condensation Polymers as Phosphate Sequestrants
  申请人：Huval Chad C.

  公开号：US20120288471A1

  公开（公告）日：2012-11-15

  Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH 2 CH 2 — group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.

  本发明涉及一种聚合物或其生理上可接受的盐。该聚合物包括聚合的多功能胺单体。该胺单体包括至少两个胺基和至少两个通过—CH2CH2—基团连接的非环状氮原子，但不包括乙二胺或二乙烯三胺。所述聚合物可用于在需要此类治疗的受试者中结合阴离子。
• POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS
  申请人：Lees Inez

  公开号：US20130189215A1

  公开（公告）日：2013-07-25

  The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

  本发明提供了交联胺聚合物，可以有效地结合和清除胆汁酸从胃肠道中。这些胆酸结合聚合物或其制药组合物可以用于治疗各种疾病，包括高胆固醇血症，糖尿病，瘙痒，肠易激综合征-腹泻（IBS-D），胆酸吸收不良等。