4-(2-methylmaleimido)benzoic acid | 83560-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-methylmaleimido)benzoic acid
• 英文别名: 4-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid；4-(3-methyl-2,5-dioxopyrrol-1-yl)benzoic acid
• CAS: 83560-88-7
• 化学式: C₁₂H₉NO₄
• mdl: MFCD11643028
• 分子量: 231.208
• InChiKey: KMCMXICWYKCOCL-UHFFFAOYSA-N

物化性质

• 沸点：
  445.2±28.0 °C(Predicted)
• 密度：
  1.438±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  柠康酸酐 、 对氨基苯甲酸 在 溶剂黄146 作用下， 以17%的产率得到4-(2-methylmaleimido)benzoic acid
  参考文献：
  名称：

  Acute effects of alkylating agents on canine renal function: specifically designed synthetic maleimides

  摘要：

  Maleimidohippurates and maleimidobenzoates were synthesized that possess a carboxy group for active uptake into renal proximal tubular cells and a reactive maleimide moiety to covalently bond with proximal tubular components. The reactivity of the maleimide moiety in each series was progressively reduced by substitution of methyl groups in place of the vinyl hydrogens. In contrast to N-ethylmaleimide (NEM), the resulting maleimidohippurates and maleimidobenzoates did not possess significant diuretic activity in the dog following renal arterial administration. However, as predicted, the nephrotoxicity of the maleimidohippurates paralleled their in vitro alkylating ability and was quite specifically located in the proximal portion of the canine renal tubule.

  DOI：

  10.1021/jm00355a017

文献信息

• Citraconimide (co)polymers and curing with anionic catalyst
  申请人：Akzo Nobel N.V.

  公开号：EP0495545A1

  公开（公告）日：1992-07-22

  A process for the preparation of a (co)polymer containing at least one unit derived from a citraconimide by curing curable composition comprising at least one substituted or unsubstituted citraconimide and a sufficient amount of an anionic curing catalyst to convert at least 10% of the citraconic alkyl groups on the citraconimide units to alkylene bridges; at a temperature above the melting point of the citraconimide unit and the product of that curing process, are disclosed. The invention also relates to the cured oligomers and articles of manufacture embodying them. These novel, cured oligomers are thermoplastic and offer several advantageous properties.

  本发明公开了一种制备含有至少一个源自柠康亚胺的单元的（共）聚合物的工艺，其方法是在高于柠康亚胺单元熔点的温度下，固化可固化组合物，该组合物包括至少一个取代或未取代的柠康亚胺和足量的阴离子固化催化剂，以将柠康亚胺单元上至少 10%的柠康烷基转化为亚烷基桥。本发明还涉及固化后的低聚物及其制造品。这些新型固化低聚物是热塑性的，具有多种优势特性。
• With maleimide groups functionalized aromatic polyamideimides, process for their preparation and their use for preparing cross-linked polymers
  申请人：CIBA-GEIGY AG

  公开号：EP0336856B1

  公开（公告）日：1993-03-03
• Process for the synthesis of citraconimides
  申请人：Akzo Nobel N.V.

  公开号：EP0495544B1

  公开（公告）日：1999-04-07
• PROCESS FOR THE MODIFICATION OF POLYPHENYLENE ETHER RESIN COMPOSITIONS
  申请人：Akzo Nobel N.V.

  公开号：EP0648240A1

  公开（公告）日：1995-04-19
• US4927900A
  申请人：——

  公开号：US4927900A

  公开（公告）日：1990-05-22