N-phenyl-N'-2-methoxyphenyl hydrazine | 952-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-N'-2-methoxyphenyl hydrazine
• 英文别名: 2-(2-phenylhydrazino)benzenemethanol；N-(2-methoxy-phenyl)-N'-phenyl-hydrazine；N-(2-Methoxy-phenyl)-N'-phenyl-hydrazin；2-Methoxy-hydrazobenzol；2-Methoxyhydrazobenzol；1-(2-Methoxyphenyl)-2-phenylhydrazine
• CAS: 952-35-2
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: SDXWUOAZFCEINI-UHFFFAOYSA-N

物化性质

• 熔点：
  84-85 °C
• 沸点：
  270.8±32.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-phenyl-N'-2-methoxyphenyl hydrazine 在 盐酸 、 三氯化铝 作用下， 生成 3-hydroxy-benzidine
  参考文献：
  名称：

  Sciarini, Archives of Biochemistry, 1957, vol. 71, p. 437,439

  摘要：

  DOI：
• 作为产物：
  描述：

  (2-methoxyphenyl)methyldiazene 在 ammonia borane 、 1,3-di-tert-butyl-2,3-dihydro-1H-1,3,2-diazaphosphole 作用下， 以 氘代乙腈 为溶剂， 反应 4.0h， 以70%的产率得到N-phenyl-N'-2-methoxyphenyl hydrazine
  参考文献：
  名称：

  协同转移氢解：1,3,2-二氮杂磷腈-氨硼烷催化的NN键加氢

  摘要：

  1,3,2-二氮杂磷烯在温和的反应条件下使用氨硼烷催化NN双键的无金属转移加氢反应，因此可以得到各种肼衍生物。动力学和计算研究表明，确定速率的步骤涉及同时破坏氨硼烷的BH和NH键。因此，该反应被认为是协同作用的氢解反应。

  DOI：

  10.1002/anie.201400099

文献信息

• Reduction of Azobenzenes to Diphenylhydrazines
  作者：Murthy R. Akula、George W. Kabalka

  DOI：10.1080/00397919608003798

  日期：1996.10

  Abstract A selective, rapid and simple reduction of azobenzenes to diphenylhydrazines using borane-THF is described.

  摘要描述了使用硼烷-THF 选择性、快速和简单地将偶氮苯还原为二苯肼。
• [EN] PYRAZOLIDINOL COMPOUNDS<br/>[FR] COMPOSES A BASE DE PYRAZOLIDINOLE
  申请人：VIRAL AS A

  公开号：WO2001000585A1

  公开（公告）日：2001-01-04

  The invention provides the use of an optionally hydroxy-protected 4-hydroxy or hydroperoxy-3,5-dioxopyrazolidine or an equivalent wherein a pyrazolidine ring attached oxygen is replaced by a sulphur, or a physiologically acceptable salt thereof, for the manufacture of a medicament for use in therapy or prophylaxis. Additionally, the invention provides a method of combatting HIV infection which comprises administering to an HIV-infected patient a T-lymphocyte growth suppressing agent, preferably a pyrazolidinol, in an amount sufficient to suppress T-lymphocyte growth in said patient for a period sufficient to reduce the T-lymphocyte concentration in lymph nodes in said patient by at least 25 % said administration being repeated at intervals of at least 3 months.

  本发明提供了使用可选的羟基保护的4-羟基或羟过氧基-3,5-二氧代吡唑烷或等效物（其中连接氧原子的吡唑烷环被硫代替），或其生理上可接受的盐，用于制备用于治疗或预防的药物。此外，本发明提供了一种抗击HIV感染的方法，该方法包括向HIV感染的患者施用T淋巴细胞生长抑制剂，优选为吡唑烷醇，其量足以在该患者中抑制T淋巴细胞生长，以使得至少25％的T淋巴细胞浓度在该患者的淋巴结中减少，该施用在至少3个月的间隔重复进行。
• Mutant IDH1 inhibitors useful for treating cancer
  申请人：THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE

  公开号：US10703746B2

  公开（公告）日：2020-07-07

  Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

  公开了式 I 和式 II 的化合物及其药学上可接受的盐 本文公开了变量 A、B、Y、Z、X1、X2、R1-4 和 R13-18。这些化合物可用于治疗癌症疾病，特别是涉及突变 IDH1 酶的疾病。还公开了含有式 I 或式 II 化合物的药物组合物以及包括施用式 I 和式 II 化合物的治疗方法。
• The Benzidine Rearrangement. Kinetics and Temperature Coefficients of the Rearrangements of Hydrazobenzene and Certain Substituted Hydrazobenzenes¹
  作者：Louis J. Croce、Joseph D. Gettler

  DOI：10.1021/ja01100a032

  日期：1953.2
• Reaction of azoarenes with tributyltin hydride
  作者：Angelo Alberti、Nicola Bedogni、Massimo Benaglia、Rino Leardini、Daniele Nanni、Gian Franco Pedulli、Antonio Tundo、Giuseppe Zanardi

  DOI：10.1021/jo00028a038

  日期：1992.1

  Tributyltin hydride when reacted with a series of substituted azoarenes afforded hydrazo compounds with high chemoselectivity and good to high yields. With ortho-substituted azoarenes, mixtures of hydrazo derivatives and N-heterocycles or cyclic products only were obtained. The kinetic law of the process was determined in the presence and in the absence of AIBN; with the radical initiator the reaction proceeds via a radical chain mechanism, whereas without AIBN the presence of stannyl free radicals could be discarded. The mechanism of the noninitiated reaction is discussed. EPR characterization of spin adducts obtained by reacting group IVB organometallic radicals with azo compounds is reported.