Methyl 4-(1,1,2,2-tetrafluoroethoxy)-2,6-dihydroxybenzoate | 131065-63-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 4-(1,1,2,2-tetrafluoroethoxy)-2,6-dihydroxybenzoate
• 英文别名: Methyl 2,6-dihydroxy-4-(1,1,2,2-tetrafluoroethoxy)benzoate
• CAS: 131065-63-9
• 化学式: C₁₀H₈F₄O₅
• 分子量: 284.164
• InChiKey: UYUHIODHXXYDAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  六氟丙烯 、 二氧化碳 、 Methyl 4-(1,1,2,2-tetrafluoroethoxy)-2,6-dihydroxybenzoate 、 硫酸二甲酯 生成 cis-1,2,3,3,3-Pentafluoro-1-phenoxypropene 、 trans-1,2,3,3,3-Pentafluoro-1-phenoxypropene 、 2,3,3,3-Tetrafluoro-1,1-diphenoxypropane 、 Methyl 2-(difluorophenoxymethyl)-2,3,3,3-tetrafluoropropanoate
  参考文献：
  名称：

  Tandem nucleophilic additions of aryloxides

  摘要：

  Hydroquinone disodium salt added sequentially to tetrafluoroethylene and carbon dioxide to yield a symmetrical dicarboxylic acid, which was transformed into the corresponding dimethyl ester, diol, diamide, and diamine. Chlorotrifluoroethylene in analogous reactions gave the corresponding diester and diol in excellent yield. When this kind of transformation was attempted on phloroglucinol, the Kolbe-Schmitt carboxylation reaction intervened. Despite serious competition from addition/elimination processes under typical reaction conditions, the tandem addition of phenoxide ion to hexafluoropropene and carbon dioxide was carried out successfully at lower temperatures and higher carbon dioxide pressures.

  DOI：

  10.1021/jo00001a031
• 作为产物：
  描述：

  四氟乙烯 、 Trisodium;benzene-1,3,5-triolate 、 硫酸二甲酯 、 二氧化碳 生成 Methyl 4-(1,1,2,2-tetrafluoroethoxy)-2,6-dihydroxybenzoate
  参考文献：
  名称：

  ARNOLD-STANTON, REGINA;LEMAL, DAVID M., J. ORG. CHEM., 56,(1991) N, C. 151-157

  摘要：

  DOI：

文献信息

• [EN] 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE 2,4-DIHYDROXYBENZOIQUE
  申请人：URIACH & CIA SA J

  公开号：WO2004009528A1

  公开（公告）日：2004-01-29

  The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the treatment or prevention of psoriasis and other immune diseases.

  本发明涉及化合物(I)及其盐、溶剂合物和前药，其中各个取代基的含义如描述所述。所述化合物可用于治疗或预防牛皮癣和其他免疫性疾病。
• 2,4-dihydroxybenzoic acid derivatives
  申请人：Bartoli Orpi Javier

  公开号：US20050267205A1

  公开（公告）日：2005-12-01

  The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the treatment or prevention of psoriasis and other immune diseases.

  本发明涉及式(I)的新化合物及其盐、溶剂合物和前药，其中各取代基的含义如说明书所述。所述化合物可用于治疗或预防牛皮癣和其他免疫性疾病。
• ARNOLD-STANTON, REGINA;LEMAL, DAVID M., J. ORG. CHEM., 56,(1991) N, C. 151-157
  作者：ARNOLD-STANTON, REGINA、LEMAL, DAVID M.

  DOI：——

  日期：——
• 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES
  申请人：J. Uriach y Compania S.A.

  公开号：EP1546084A1

  公开（公告）日：2005-06-29
• US7589125B2
  申请人：——

  公开号：US7589125B2

  公开（公告）日：2009-09-15