Z-Pro-Leu-Gly-NHOH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Pro-Leu-Gly-NHOH
• 英文别名: benzyl (2S)-2-[[(2S)-1-[[2-(hydroxyamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
• 化学式: C₂₁H₃₀N₄O₆
• mdl: MFCD00083286
• 分子量: 434.5
• InChiKey: VVGFLHRPYCTXGJ-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.523
• 拓扑面积：
  137
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  Z-Pro-Leu-Gly-OH 生成 Z-Pro-Leu-Gly-NHOH
  参考文献：
  名称：

  SPIBURG, CURTIS A.;MOORE, WILLIAM M.

  摘要：

  DOI：

文献信息

• NOVEL HYDROXAMIC ACID DERIVATIVE
  申请人：FUJI YAKUHIN KOGYO KABUSHIKI KAISHA

  公开号：EP0345359A1

  公开（公告）日：1989-12-13

  A novel peptide derivative compound which is expected to be useful for treatment of such diseases as rheumatoid arthritis. periodontal disease, corneal ulcer and epidermolysis bul- losa. and which is a hydroxamic acid derivative of a tetrapeptide and has the action of specifically inhibiting collagenase of vertebrate ongin.

  一种新型肽衍生物化合物，有望用于治疗类风湿性关节炎、牙周病、角膜溃疡和大疱性表皮松解症等疾病，该化合物是一种四肽的羟肟酸衍生物，具有特异性抑制脊椎动物本体胶原酶的作用。
• NOVEL PROTEIN AND DNA THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1111047A2

  公开（公告）日：2001-06-27

  The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.

  本发明涉及一种属于ADAM家族的新型蛋白质、其部分肽或盐、编码该蛋白质的DNA、包含该DNA的重组载体、转化体、生产该蛋白质的方法、包含该蛋白质或该DNA的药物、抗该蛋白质的抗体、用于筛选促进或抑制该蛋白质的蛋白酶活性或细胞外元降解酶活性（最好是肽聚糖降解酶活性）的化合物或其盐的方法/试剂盒、通过筛选获得的化合物以及包含该化合物的药物。 例如，本蛋白和编码本蛋白的 DNA 可用作治疗或预防各种疾病的药物，如椎间盘突出症、峡部痛、肾小球肾炎、糖尿病肾病、肝纤维化、肺纤维化或骨化症。此外，本抗体还可用于定量检测溶液中的本蛋白。此外，本蛋白还可作为一种试剂，用于筛选促进或抑制本蛋白蛋白酶活性的化合物。
• Novel protein and DNA thereof
  申请人：——

  公开号：US20040132157A1

  公开（公告）日：2004-07-08

  The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.

  本发明涉及一种属于ADAM家族的新型蛋白质、其部分肽或盐、编码该蛋白质的DNA、包含该DNA的重组载体、转化体、生产该蛋白质的方法、包含该蛋白质或该DNA的药物、抗该蛋白质的抗体、用于筛选促进或抑制该蛋白质的蛋白酶活性或细胞外元降解酶活性（最好是肽聚糖降解酶活性）的化合物或其盐的方法/试剂盒、通过筛选获得的化合物以及包含该化合物的药物。 例如，本蛋白和编码本蛋白的 DNA 可用作治疗或预防各种疾病的药物，如椎间盘突出症、峡部痛、肾小球肾炎、糖尿病肾病、肝纤维化、肺纤维化或骨化症。此外，本抗体还可用于定量检测溶液中的本蛋白。此外，本蛋白还可作为一种试剂，用于筛选促进或抑制本蛋白蛋白酶活性的化合物。
• SPILBURG, CURTIS A.;MOORE, WILLIAM MCC.
  作者：SPILBURG, CURTIS A.、MOORE, WILLIAM MCC.

  DOI：——

  日期：——
• SPIBURG, CURTIS A.;MOORE, WILLIAM M.
  作者：SPIBURG, CURTIS A.、MOORE, WILLIAM M.

  DOI：——

  日期：——