2-(4-pyridyl)-3H-pyrido<4,3-d>pyrimidin-4-one | 139452-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(4-pyridyl)-3H-pyrido<4,3-d>pyrimidin-4-one
• 英文别名: 2-(4-pyridyl)-3H-pyrido[4,3-d]pyrimidin-4-one；2-Pyridin-4-yl-3h-pyrido[4,3-d]pyrimidin-4-one；2-pyridin-4-yl-3H-pyrido[4,3-d]pyrimidin-4-one
• CAS: 139452-58-7
• 化学式: C₁₂H₈N₄O
• 分子量: 224.222
• InChiKey: CAAVORZZIVVFLM-UHFFFAOYSA-N

物化性质

• 沸点：
  458.4±43.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-pyridyl)-3H-pyrido<4,3-d>pyrimidin-4-one 在 三氯氧磷 作用下， 以 异丙醇 为溶剂， 生成 N-(4-methyl-1H-indol-5-yl)-2-pyridin-4-ylpyrido[4,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  WO2020142748A5

  摘要：

  公开号：

  WO2020142748A5
• 作为产物：
  描述：

  4-amidinopyridine hydrochloride 在 palladium on activated charcoal sodium ethanolate 作用下， 以 乙醇 、 xylene 为溶剂， 反应 12.0h， 生成 2-(4-pyridyl)-3H-pyrido<4,3-d>pyrimidin-4-one
  参考文献：
  名称：

  Huber, Imre; Fueloep, Ferenc; Lazar, Janos, Journal of the Chemical Society. Perkin transactions I, 1992, # 1, p. 157 - 162

  摘要：

  DOI：

文献信息

• [EN] 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS<br/>[FR] PYRIMIDINES 4-AMINO-2-PYRIDO-BICYCLIQUES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA TOPOISOMÉRASE II
  申请人：FONDAZIONE ST ITALIANO TECNOLOGIA

  公开号：WO2018114700A1

  公开（公告）日：2018-06-28

  The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines as type II topoisomerase inhibitors and use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4- amino-2-pyrido bicyclic pyrimidines.

  本发明涉及4-氨基-2-吡啶双环嘧啶作为II型拓扑异构酶抑制剂及其用途作为药物，特别是在癌症治疗中的用途。该发明还提供了一种制备4-氨基-2-吡啶双环嘧啶的方法。
• 4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors
  申请人：FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：US10889560B2

  公开（公告）日：2021-01-12

  The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).

  本发明涉及作为II型拓扑异构酶抑制剂的式(I)的4-氨基-2-吡啶双环嘧啶及其作为药物的用途，特别是在癌症治疗中的用途。 本发明还提供了一种制造式（I）的4-氨基-2-吡啶双环嘧啶的方法。
• 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS
  申请人：Fondazione Istituto Italiano di Tecnologia

  公开号：EP3558964A1

  公开（公告）日：2019-10-30
• [EN] METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR AUGMENTER LES NIVEAUX DE POLYPEPTIDES EB DE FACTEUR DE TRANSCRIPTION
  申请人：UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION

  公开号：WO2020142748A1

  公开（公告）日：2020-07-09

  This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.