(Z)-3,4,4-Trimethyl-pent-2-enoic acid | 134750-24-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-3,4,4-Trimethyl-pent-2-enoic acid
• 英文别名: 2-Pentenoic acid, 3,4,4-trimethyl-, (Z)-；(Z)-3,4,4-trimethylpent-2-enoic acid
• CAS: 134750-24-6
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: NFLSFCFOAOZXFO-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-3,4,4-Trimethyl-pent-2-enoic acid 在 二苯基膦酰羟胺 、 lithium diethylamide 作用下， 生成 2-Amino-4,4-dimethyl-3-methylene-pentanoic acid
  参考文献：
  名称：

  Polyenolates of Unsaturated Carboxylic Acids in Synthesis. Synthesis of Unsaturated α-Amino Acids and β-Hydrazing Acids

  摘要：

  Regioselective reaction of lithium dieneand triene-diolates 1 and 2 with o-diphenylphosphinyl hydroxylamine affords unsaturated alpha-amino acids 3 and 4. Addition to DEAD leads selectively to gamma-hydrazino unsaturated acids 5 and 6.

  DOI：

  10.1080/00397919108021773

文献信息

• Iodine oxidative coupling of diene and triene-diolates of unsaturated carboxylic acids.
  作者：M.J. Aurell、S. Gil、M. Parra、A. Tortajada、R. Mestres

  DOI：10.1016/s0040-4020(01)96111-3

  日期：1991.3

  Oxidative Coupling of the dianions of unsaturated carboxylic acids 1, and 4 with iodine, which provides a convenient and facile preparation of γ,γ and ε,ε-dicarboxylic acids 2 and 5, apparently occurs through SET substitution of intermediate iodo-carboxylates.

  不饱和羧酸1和4的二价阴离子与碘的氧化偶联，提供了便捷，简便的γ，γ和ε，ε-二羧酸2和5的制备方法，显然是通过中间碘代羧酸盐的SET取代实现的。
• Polyenolates of Unsaturated Carboxylic Acids in Synthesis. Synthesis of Unsaturated α-Amino Acids and β-Hydrazing Acids
  作者：M. J. Aurell、S. Gil、P. V. Martinez、M. Parra、A. Tortajada、R. Mestres

  DOI：10.1080/00397919108021773

  日期：1991.9

  Regioselective reaction of lithium dieneand triene-diolates 1 and 2 with o-diphenylphosphinyl hydroxylamine affords unsaturated alpha-amino acids 3 and 4. Addition to DEAD leads selectively to gamma-hydrazino unsaturated acids 5 and 6.