2-氨基-5-(二氨基亚甲基氨基)-N-(4-硝基苯基)戊酰胺 | 76847-45-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-氨基-5-(二氨基亚甲基氨基)-N-(4-硝基苯基)戊酰胺
• 英文名称: 2-amino-5-guanidino-N-(4-nitrophenyl)pentanamide
• 英文别名: 2-Amino-5-guanidino-pentanoic acid (4-nitro-phenyl)-amide；Arginine-4-nitroanilide；2-amino-5-(diaminomethylideneamino)-N-(4-nitrophenyl)pentanamide
• CAS: 76847-45-5
• 化学式: C₁₂H₁₈N₆O₃
• 分子量: 294.313
• InChiKey: TWYRZWVFWYSNBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  165
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2925290090

文献信息

• DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION
  申请人：Dietz Ulrich

  公开号：US20130090488A1

  公开（公告）日：2013-04-11

  The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及溶解化合物、用于从油、脂肪、水乳液、水介质和有机溶液中溶解和去除羧酸，特别是脂肪酸的装置和方法。采用本发明方法的装置将用于通过制备羧酸特别是脂肪酸和含有至少一种氨基甲酰基和/或肼基团的溶解化合物的水微观或纳米乳液，分离油、脂肪、水乳液、亲脂性介质或有机溶液中的羧酸。溶解化合物的溶解效果与本发明所述的羧酸分离方法相结合，可用于治疗需要去除脂肪酸或从血液中分析羧酸或处理食品、药品、化学、生物燃料工业或其他工业加工过程中的其他溶液的人员。
• Peptide-type substrates useful in the quantitative determination of endotoxin
  申请人：WHITTAKER CORPORATION

  公开号：EP0074761A1

  公开（公告）日：1983-03-23

  Disclosed are chromogenic or fluorogenic peptide-type compounds adapted for use in determining endotoxin in a sample by a Limulus amebocyte lysate-type assay. The compounds have the general formula:wherein R, represents hydrogen, a blocking aromatic hydrocarbon or acyl; A1 represents an L or D-amino acid selected from either lieu, Val or Leu; A2 represents Glu or Asp; A3 represents Ala or Cyst; A4 represents Arg, B represents a linkage group selected from ester and amide linkage groups; and R2 represents a chromogenic orfluorogenic group which is covalently attached to the C-carboxyl terminal of arginine through the B linkage group and which yields a chromophoric or fluorescent marker compound of the formula R2-B-H upon enzymatic hydrolysis from the remainder of the peptide-type compound by activated LAL pro-clot enzyme. Also disclosed are methods for the determination of endotoxin in a sample by contacting the sample with a pro-clotting enzyme from Limulus amebocyte lysate and one of the above chromogenic or fluorogenic peptide-type compounds.

  本发明公开了一些发色性或发荧光性的肽类化合物，适用于通过纤毛虫卵母细胞裂解物类检测法确定样品中的内毒素。这些化合物具有通式：其中 R 代表氢、阻塞芳香烃或酰基；A1 代表选自 lieu、Val 或 Leu 的 L 或 D-氨基酸；A2 代表 Glu 或 Asp；A3 代表 Ala 或 Cyst；A4 代表 Arg，B 代表选自酯和酰胺连接基团的连接基团；以及 R2 代表发色或发荧光基团，该基团通过 B 连接基团共价连接到精氨酸的 C 羧基末端，并在活化的 LAL 原凝血酶从肽型化合物的剩余部分进行酶水解时产生式 R2-B-H 的发色或发荧光标记化合物。本发明还公开了测定样品中内毒素的方法，该方法是将样品与来自纤毛虫卵母细胞裂解物的促凝血酶和上述发色性或发荧光性肽类化合物之一接触。
• Use of specific properties of allergens from animal sources and methods for their isolation
  申请人：C.B.F. LETI, S.A.

  公开号：EP0377229A1

  公开（公告）日：1990-07-11

  It was found that atopic allergens have enzymatic properties, in particular the properties to hydrolyse amide and/or ester linka­ges or organic phosphate esters. These properties may be used for various purposes, e.g. for analysis of samples, standardization of pharmaceutical compositions and also for the preparation of the allergens in a pure form.

  研究发现，特应性过敏原具有酶的特性，尤其是水解酰胺和/或酯连接或有机磷酸酯的特性。这些特性可用于多种用途，如样品分析、药物成分标准化以及制备纯净形式的过敏原。
• Gelated microparticle suitable for oral delivery of therapeutic peptides to the lower intestine
  申请人：Insucaps Limited

  公开号：US10092517B2

  公开（公告）日：2018-10-09

  A gelated microparticle suitable for delivery intact to the mammalian lower intestine via an oral route comprises a monodispersed matrix formed of at least partially hydrolyzed casein, chitosan, and an active agent, and includes a minor amount of at least one permeation enhancer dispersed throughout the matrix.

  适用于通过口服途径将药物完整地输送到哺乳动物下肠的凝胶状微粒包括由至少部分水解的酪蛋白、壳聚糖和活性剂形成的单分散基质，还包括分散在整个基质中的少量至少一种渗透增强剂。
• INHIBITORS OF CYSTEINE PEPTIDASES ISOLATED FROM NATURAL RAW MATERIALS AND USE OF THE INHIBITORS IN MEDICINE AND VETERINARY MEDICINE
  申请人：Rapak, Andrzej Marek

  公开号：EP3923976A1

  公开（公告）日：2021-12-22