2-amino-2-methylpropyl acetate | 25000-26-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-2-methylpropyl acetate
• 英文别名: 2-Amino-2-methyl-1-acetoxy-propan；2-Amino-2-methyl-1-propylacetat；2-Acetoxymethyl-2-amino-propan；Dimethyl-aminoethyl acetate；(2-amino-2-methylpropyl) acetate
• CAS: 25000-26-4
• 化学式: C₆H₁₃NO₂
• mdl: MFCD19204006
• 分子量: 131.175
• InChiKey: SFRWMZNGJPNGEZ-UHFFFAOYSA-N

物化性质

• 沸点：
  169.0±23.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-chloro-2-acetylamino-2-methylpropane 在 水 作用下， 以 甲醇 为溶剂， 生成 2-amino-2-methylpropyl acetate
  参考文献：
  名称：

  Beger,J. et al., Journal fur praktische Chemie (Leipzig 1954), 1969, vol. 311, p. 15 - 35

  摘要：

  DOI：

文献信息

• N-Halo Derivatives IV: Synthesis of Low Chlorine Potential Soft N-Chloramine Systems
  作者：James J. Kaminski、Nicolae Bodor、Takeru Higuchi

  DOI：10.1002/jps.2600651210

  日期：1976.12

  A number of low chlorine potential, soft N-chloramines containing nitrogen-chlorine bonds of different polarity were prepared. These novel N-chloramine systems were based on derivatization of 2-amino-2-methyl-1-propanol.

  制备了许多低氯势，柔软的N-氯胺，它们含有不同极性的N-氯键。这些新颖的N-氯胺系统基于2-氨基-2-甲基-1-丙醇的衍生化。
• Metal-Free <i>O</i> -Selective Direct Acylation of Amino Alcohols Through Pseudo-Intramolecular Process
  作者：Soichi Yokoyama、Hiroshi Shibauchi、Haruyasu Asahara、Nagatoshi Nishiwaki

  DOI：10.1002/ejoc.201801589

  日期：2019.2.7

  Acylation of diamines using α‐aryl‐β‐keto esters occurs regioselectively at the less hindered amino group. The transacylation using N‐alkylamino alcohol resulted in chemoselective O‐acylation in the absence of metal catalyst. Protection of the amino group is not necessary. These reactions proceed efficiently because of the pseudo‐intramolecular process.

  使用α-芳基-β-酮酸酯对二胺进行酰化反应会在较低受阻氨基上区域选择性地发生。在没有金属催化剂的情况下，使用N-烷基氨基醇进行的酰基转移反应会导致化学选择性的O-酰基化反应。不需要保护氨基。由于拟分子内过程，这些反应有效地进行。
• Method for detecting a substance in a sample
  申请人：TOSOH CORPORATION

  公开号：EP0347256A2

  公开（公告）日：1989-12-20

  A method for detecting a substance in a sample which comprises steps of: (a) mixing a first enzyme complex comprising a first enzyme bound to a material having the affinity for the substance to be detected with the sample, (b) separating the first enzyme complex bound to the substance to be detected (the first enzyme complex in bound form) from the first enzyme complex not bound to the substance to be detected (the first enzyme complex in free form), (c) reacting the first enzyme complex in bound form with (i) a first substrate comprising a substrate for said first enzyme which is bound to a second enzyme; or (ii) a first substrate comprising a substrate to said first enzyme which is not bound to a second enzyme, (d) removing the unreacted first substrate from the first product formed in step (i); or reacting the first product formed in step (ii) with a second enzyme complex comprising a second enzyme bound to a material having the affinity for said first product, and then removing the unreacted second enzyme complex, (e) reacting the system with a second substrate to the second enzyme to form a second product, and (f) detecting the second product produced in step (e).

  一种检测样品中物质的方法，包括以下步骤 (a) 将第一酶复合物与样品混合，第一酶复合物包括与待检测物质具有亲和力的 材料结合的第一酶、 (b) 将与待检测物质结合的第一种酶复合物（结合形式的第一种酶复合物）与未与待检测物质结合的第一种酶复合物（游离形式的第一种酶复合物）分离、 (c) 使结合形式的第一酶复合物与 (i) 第一底物反应，该底物包括与第二酶结合的所述第一酶的底物；或 (ii) 第一底物反应，该底物包括与第二酶未结合的所述第一酶的底物、 (d) 从步骤(i)中形成的第一产物中除去未反应的第一底物；或 将步骤(ii)中形成的第一产物与第二酶复合物反应，第二酶复合物包括与对所述第一产物具有亲和力的材料结合的第二酶，然后除去未反应的第二酶复合物、 (e) 用第二种底物与第二种酶反应，形成第二种产物，以及 (f) 检测步骤(e)中产生的第二产物。
• Immunoassay on a preblocked solid surface
  申请人：Becton Dickinson and Company

  公开号：EP0369361A2

  公开（公告）日：1990-05-23

  A method for immunoassay of a viral antigen is performed on a membrane precoated with an inert protein. Nonimmunological capture of antigen takes place by absorption onto the coated membrane. Captured antigen binds to a tracer which includes a label conjugated to a specific antibody, the inert protein concomitantly inhibiting nonspecific binding of tracer. The label may be an enzyme which converts a substrate to a detectable product or converts a blocked inhibitor to an inhibitor whereby a second enzyme is inhibited from converting a substrate to a product. The invention includes a kit of materials for performing an assay in accordance with the method of the invention.

  病毒抗原的免疫测定方法是在预先涂有惰性蛋白质的膜上进行的。抗原通过被涂膜吸收而被非免疫捕获。捕获的抗原与示踪剂结合，示踪剂包括与特异性抗体结合的标签，惰性蛋白同时抑制示踪剂的非特异性结合。标签可以是一种酶，它能将底物转化为可检测的产物，或将被阻断的抑制剂转化为抑制剂，从而抑制第二种酶将底物转化为产物。本发明包括一套材料，用于按照本发明的方法进行检测。
• Substrate composition for alkaline phosphatase and method for assay using same
  申请人：Becton Dickinson and Company

  公开号：EP0369362A2

  公开（公告）日：1990-05-23

  A composition contains levamisole and a substrate for alkaline phosphatase in a high pH buffer including 2-amino-2-methyl-1-propanol. The composi­tion may be included in a kit of materials useful in performing an immunoassay in which intestinal alkaline phosphatase is the label. The invention includes a method for detection of a viral antigen by an immunoassay including intestinal alkaline phosphatase as the label and the composition of the invention to provide stabilized levamisole to inhibit nonintestinal alkaline phosphatase.

  一种组合物含有左旋咪唑和碱性磷酸酶底物，在高 pH 缓冲液中，包括 2-氨基-2-甲基-1-丙醇。该组合物可包含在用于进行以肠碱性磷酸酶为标记的免疫测定的材料试剂盒中。本发明包括一种用免疫测定法检测病毒抗原的方法，该方法包括以肠碱性磷酸酶为标记的免疫测定法和本发明的组合物，以提供稳定的左旋咪唑来抑制非肠碱性磷酸酶。