2-氨基-5-溴-3-(乙氨基)吡嗪 | 117719-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-氨基-5-溴-3-(乙氨基)吡嗪
• 中文别名: 2-氨基-5-溴-3-乙基氨基吡嗪
• 英文名称: 2-amino-5-bromo-3-(ethylamino)pyrazine
• 英文别名: 5-bromo-3-N-ethylpyrazine-2,3-diamine
• CAS: 117719-10-5
• 化学式: C₆H₉BrN₄
• 分子量: 217.068
• InChiKey: FYOJEGNMDFDYBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-溴-3-甲氧基丙醛 、 2-氨基-5-溴-3-(乙氨基)吡嗪 以 N,N-二甲基甲酰胺 、 乙醇 为溶剂， 反应 50.0h， 以30%的产率得到(6-Bromo-3-methoxymethyl-imidazo[1,2-a]pyrazin-8-yl)-ethyl-amine
  参考文献：
  名称：

  New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities

  摘要：

  lNew imidazo[1,2-a]pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions: The presence nf electron donating groups On position 8 greatly enhances the reactivity of the heterocycle towards such reactions on position 3 of the heterocycle. The activities of these derivatives in trachealis muscle relaxation and in inhihiting cyclic nucleotide phosphodiesterase(PDE) isoenzyme types III and IV have been assessed All compounds demonstrated higher relaxant potency than theophylline. All the derivatives were moderately potent in inhibiting the type IV isoenzyme of PDE but only those with a cyano group on position 2 were potent in inhibiting the type III isoenzyme. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00019-x
• 作为产物：
  描述：

  乙胺 、 2-氨基-3,5-二溴吡嗪 以 水 为溶剂， 以84%的产率得到2-氨基-5-溴-3-(乙氨基)吡嗪
  参考文献：
  名称：

  New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities

  摘要：

  lNew imidazo[1,2-a]pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions: The presence nf electron donating groups On position 8 greatly enhances the reactivity of the heterocycle towards such reactions on position 3 of the heterocycle. The activities of these derivatives in trachealis muscle relaxation and in inhihiting cyclic nucleotide phosphodiesterase(PDE) isoenzyme types III and IV have been assessed All compounds demonstrated higher relaxant potency than theophylline. All the derivatives were moderately potent in inhibiting the type IV isoenzyme of PDE but only those with a cyano group on position 2 were potent in inhibiting the type III isoenzyme. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00019-x

文献信息

• New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities
  作者：Olivier Vitse、Florence Laurent、Tristan M. Pocock、Véronique Bénézech、Lahcen Zanik、Keith R.F. Elliott、Guy Subra、Karine Portet、Jacques Bompart、Jean-Pierre Chapat、Roger C. Small、Alain Michel、Pierre-Antoine Bonnet

  DOI：10.1016/s0968-0896(99)00019-x

  日期：1999.6

  lNew imidazo[1,2-a]pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions: The presence nf electron donating groups On position 8 greatly enhances the reactivity of the heterocycle towards such reactions on position 3 of the heterocycle. The activities of these derivatives in trachealis muscle relaxation and in inhihiting cyclic nucleotide phosphodiesterase(PDE) isoenzyme types III and IV have been assessed All compounds demonstrated higher relaxant potency than theophylline. All the derivatives were moderately potent in inhibiting the type IV isoenzyme of PDE but only those with a cyano group on position 2 were potent in inhibiting the type III isoenzyme. (C) 1999 Elsevier Science Ltd. All rights reserved.