8-Trifluoracetylamino-caprylsaeure | 61948-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-Trifluoracetylamino-caprylsaeure
• 英文别名: N-trifluoroacetyl-8-amino-n-caprylic acid；8-(2,2,2-Trifluoroacetamido)octanoic acid；8-[(2,2,2-trifluoroacetyl)amino]octanoic acid
• CAS: 61948-19-4
• 化学式: C₁₀H₁₆F₃NO₃
• 分子量: 255.237
• InChiKey: SUQVCCQOMHZAAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  V6Pxe6SA7G 、 8-Trifluoracetylamino-caprylsaeure 生成 [3-[[(2R,3aS,4R,6S,7R,7aS)-7-[(2R,3R,4S,5S,6R)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methyl-2-phenyl-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-6-yl]oxy]-15-methyl-10,17-dioxo-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaen-8-yl] 8-[(2,2,2-trifluoroacetyl)amino]octanoate
  参考文献：
  名称：

  KON, KENJI;SUGI, HIDEO;TAMAI, KIYOSHI;UEDA, YOSHIMICHI;YAMADA, NOBUTOSHI, J. ANTIBIOTICS, 43,(1990) N, C. 372-382

  摘要：

  DOI：

文献信息

• Chartreusin derivatives, salts thereof, antitumorous compositions containing the same, and processes for produing the same
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP0159708A2

  公开（公告）日：1985-10-30

  This invention relates to a novel chartreusin derivative of the general formula (I): and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.

  本发明涉及一种通式为(I)的新型石杉碱衍生物及其盐。 这种石杉碱衍生物及其盐具有优异的抗肿瘤活性，即使癌症接种部位和给药部位不同也能显示出这种活性。 本发明还涉及一种含有上述化合物作为活性成分的抗肿瘤组合物。 本发明还涉及一种生产上述石杉碱衍生物或其盐的工艺。
• Chartreusin derivatives, salts thereof, antitumorous compositions containing the same, and processes for producing the same
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP0219852A2

  公开（公告）日：1987-04-29

  This invention relates to a novel chartreusin derivative of the general formula (I): and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.

  本发明涉及一种通式 (I) 的新型海藻糖苷衍生物： 及其盐。这种石杉碱衍生物及其盐具有极佳的抗肿瘤活性，即使癌症接种部位和给药部位不同，也能显示出这种活性。本发明还涉及一种含有上述化合物作为活性成分的抗肿瘤组合物。本发明还涉及生产上述石杉碱衍生物或其盐的工艺。
• KON, KENJI;SUGI, HIDEO;TAMAI, KIYOSHI;UEDA, YOSHIMICHI;YAMADA, NOBUTOSHI, J. ANTIBIOTICS, 43,(1990) N, C. 372-382
  作者：KON, KENJI、SUGI, HIDEO、TAMAI, KIYOSHI、UEDA, YOSHIMICHI、YAMADA, NOBUTOSHI

  DOI：——

  日期：——
• MORI, XIROYUKI;YAMADA, SYUBEHN;SUGI, XIDEHO;KON, KEHNDZI
  作者：MORI, XIROYUKI、YAMADA, SYUBEHN、SUGI, XIDEHO、KON, KEHNDZI

  DOI：——

  日期：——
• US4760136A
  申请人：——

  公开号：US4760136A

  公开（公告）日：1988-07-26