2-methoxy-5-methyl-mandelic acid-ethyl ester | 91555-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-methoxy-5-methyl-mandelic acid-ethyl ester
• 英文别名: 2-Methoxy-5-methyl-mandelsaeure-aethylester；Ethyl 2-hydroxy-2-(2-methoxy-5-methylphenyl)acetate
• CAS: 91555-52-1
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: KEAUCFVSBAEVTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methoxy-5-methyl-mandelic acid-ethyl ester 在 sodium hydroxide 作用下， 生成 2-methoxy-5-methyl-mandelic acid
  参考文献：
  名称：

  Intrathecal morphine suppresses NK cell activity following abdominal surgery

  摘要：

  Purpose: The effects of morphine on natural killer (NK) cell activity were investigated in patients who underwent hysterectomy.Methods: Forty patients were divided into four groups often. The groups received intrathecal 0.5 mg morphine (Group IT0.5), intrathecal 0.1 mg morphine (Group IT0.1) or 10 mg morphine iv (Group IV). The remaining ten patients served as controls and received inhalation anesthesia alone (Group C). Blood samples were withdrawn before and two hours after surgery and on postoperative days one and two to determine the blood NK cell activity using a chromium release assay with K562 cells as targets, plasma catecholamines and cortisol levels. The post operative pain score and side effects were studied in the four groups.Results: In Group IT0.5, the NK cell activity was lower on postoperative day 1 (23.9 +/- 8.4%) than the baseline level (45.7 +/- 13%) before surgery, and recovered on postoperative day 2. in Groups IT0.1 C and IV, the NK cell activities showed no significant changes. In all four groups, neither plasma adrenaline nor noradrenaline concentrations changed. In all four groups, the plasma cortisol levels increased after surgery, on postoperative days 1 and 2. The pain score was lower two hours after surgery and on postoperative day 1 in Group Ito, than in the other groups.Conclusion: These results suggest that long-lasting analgesic effects of intrathecal 0.5 mg morphine suppress the immune response following abdominal surgery.

  DOI：

  10.1007/bf03020942
• 作为产物：
  描述：

  乙基(2-甲氧基-5-甲基苯基)(氧代)乙酸酯 在 乙醇 、 钯 作用下， 生成 2-methoxy-5-methyl-mandelic acid-ethyl ester
  参考文献：
  名称：

  Kindler; Metzendorf; Kwok, Chemische Berichte, 1943, vol. 76, p. 308,314

  摘要：

  DOI：

文献信息

• Ytterbium(III) Trifluoromethanesulfonate Catalyzed Electrophilic Aromatic Substitution with Glyoxalate and Lipase-Mediated Product Resolution:  A Convenient Route to Optically Active Aromatic α-Hydroxy Esters
  作者：Wei Zhang、Peng George Wang

  DOI：10.1021/jo991916v

  日期：2000.7.1