1-methoxy-4-methyl-2-(1-phenylethyl)benzene | 521982-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methoxy-4-methyl-2-(1-phenylethyl)benzene
• 英文别名: 1-Methoxy-4-methyl-2-(1-phenylethyl)benzene
• CAS: 521982-26-3
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: YREFIOUPLBXTFV-UHFFFAOYSA-N

物化性质

• 沸点：
  332.0±21.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对甲苯甲醚 、 苏合香醇 在 silver hexafluoroantimonate 、 三苯基膦氯金 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.5h， 以99%的产率得到1-methoxy-4-methyl-2-(1-phenylethyl)benzene
  参考文献：
  名称：

  金催化的苯甲醛醇类的弗里德尔-克拉夫特类似反应对Afford 1,1-二芳基烷烃的反应

  摘要：

  已经开发了一种金催化的未活化的苄醇的弗里德尔-克拉夫茨样苄基化反应，形成1,1-二芳基烷烃。操作简便的方法仅使用1.3当量的富电子芳烃，采用容易获得的起始原料，具有高度重现性，并且耐潮。获得了中等到高的产品收率（34–99％），具有出色的区域选择性。

  DOI：

  10.1002/ejoc.201901082

文献信息

• Iron Oxide Nanoparticles Grown on Carboxy-Functionalized Graphite: An Efficient Reusable Catalyst for Alkylation of Arenes
  作者：Vikul Rajpara、Subhash Banerjee、Grigoriy Sereda

  DOI：10.1055/s-0029-1218851

  日期：2010.8

  hybrid catalyst by growing iron oxide nanoparticles on carboxy-functionalized graphite. This hybrid catalyst demonstrated superior catalytic activity towards the alkylation of arenes with alkyl halides in contrast to commercial graphite or unsupported iron oxide nanoparticles in terms of yields and general applicability. The catalyst can be reused up to five times with a minimal loss of catalytic activity

  在这里，我们报告了通过在羧基官能化的石墨上生长氧化铁纳米颗粒来合成新型杂化催化剂的简单程序。与市售的石墨或无载体的氧化铁纳米颗粒相比，该杂化催化剂在芳烃与烷基卤化物的烷基化方面显示出优异的催化活性，这在产率和通用性方面均如此。催化剂可以重复使用多达五次，而催化活性损失最小。 氧化铁纳米粒子-氧化石墨载体-烷基化-催化-可重用性
• Tin exchanged heteropoly tungstate: An efficient catalyst for benzylation of arenes with benzyl alcohol
  作者：Ch. Ramesh Kumar、K.T. Venkateswara Rao、P.S. Sai Prasad、N. Lingaiah

  DOI：10.1016/j.molcata.2011.01.008

  日期：2011.3

  The partial exchange of tin with the protons of 12-tungstophosphoric acid (TPA) results in a highly active heterogeneous catalyst for benzylation of arenes with benzyl alcohol as benzylating agent. The catalysts were characterized by X-ray diffraction, Laser-Raman and FT-IR of pyridine adsorption. The catalytic activity depends significantly on the extent of tin exchanged with the protons of heteropoly tungstate. The characterization results suggest the presence of Lewis acidic sites by the exchange of tin. The catalyst with partial exchange of Sn showed high benzylation activity, which in turn related to variation in acidity of the catalysts. The catalyst is highly active for benzylation reaction irrespective of the nature of substituted arenes and benzyl alcohols. These catalysts are highly active compared to other acid catalysts used for benzylation of different arenes. The catalyst is easy to separate from reaction mixture and exhibit consistent activity upon reuse. The plausible reaction mechanism based on the role of both Lewis and Bronsted acid sites of the catalyst was discussed. (C) 2011 Elsevier B.V. All rights reserved.
• Gold-Catalyzed Friedel-Crafts-Like Reaction of Benzylic Alcohols to Afford 1,1-Diarylalkanes
  作者：James V. Oakley、Tyler J. Stanley、Kate A. Jesse、Amanda K. Melanese、Araceli A. Alvarez、Aloha L. Prince、Stephanie E. Cain、Anna G. Wenzel、Robert G. Iafe

  DOI：10.1002/ejoc.201901082

  日期：2019.11.14

  A gold‐catalyzed, Friedel–Crafts‐like benzylation of unactivated benzylic alcohols to form 1,1‐diarylalkanes has been developed. The operationally convenient method uses only 1.3 equivalents of electron‐rich arene, employs readily available starting materials, is highly reproducible, and is tolerant to moisture. Moderate‐to‐high product yields (34–99 %) with excellent regioselectivity were obtained

  已经开发了一种金催化的未活化的苄醇的弗里德尔-克拉夫茨样苄基化反应，形成1,1-二芳基烷烃。操作简便的方法仅使用1.3当量的富电子芳烃，采用容易获得的起始原料，具有高度重现性，并且耐潮。获得了中等到高的产品收率（34–99％），具有出色的区域选择性。