4-chloro-2-methyl-6-(2-pyridyl)pyrimidine | 25194-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-chloro-2-methyl-6-(2-pyridyl)pyrimidine
• 英文别名: 4-Chloro-2-methyl-6-(pyridin-2-yl)pyrimidine；4-chloro-2-methyl-6-pyridin-2-ylpyrimidine
• CAS: 25194-62-1
• 化学式: C₁₀H₈ClN₃
• mdl: MFCD01646076
• 分子量: 205.647
• InChiKey: ZWHZRLMJZKIKGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloro-2-methyl-6-(2-pyridyl)pyrimidine 、 对氯苄胺 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成 N-(4-chlorobenzyl)-2-methyl-6-(pyridin-2-yl)pyrimidin-4-amine
  参考文献：
  名称：

  Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists

  摘要：

  The identification of highly potent and orally bioavailable GPR39 agonists is reported. Compound 1, found in a phenotypic screening campaign, was transformed into compound 2 with good activity on both the rat and human GPR39 receptor. This compound was further optimized to improve ligand efficiency and pharmacokinetic properties to yield GPR39 agonists for the potential oral treatment of type 2 diabetes. Thus, compound 3 is the first potent GPR39 agonist (EC(50)s <= 1 nM for human and rat receptor) that is orally bioavailable in mice and robustly induced acute GLP-1 levels.

  DOI：

  10.1021/ml500240d
• 作为产物：
  描述：

  皮考林乙酸乙酯 在 potassium carbonate 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 4-chloro-2-methyl-6-(2-pyridyl)pyrimidine
  参考文献：
  名称：

  Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists

  摘要：

  The identification of highly potent and orally bioavailable GPR39 agonists is reported. Compound 1, found in a phenotypic screening campaign, was transformed into compound 2 with good activity on both the rat and human GPR39 receptor. This compound was further optimized to improve ligand efficiency and pharmacokinetic properties to yield GPR39 agonists for the potential oral treatment of type 2 diabetes. Thus, compound 3 is the first potent GPR39 agonist (EC(50)s <= 1 nM for human and rat receptor) that is orally bioavailable in mice and robustly induced acute GLP-1 levels.

  DOI：

  10.1021/ml500240d

文献信息

• [EN] PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL<br/>[FR] COMPOSÉ PYRIMIDINE ET SON UTILISATION DANS LA LUTTE ANTIPARASITAIRE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2010134478A1

  公开（公告）日：2010-11-25

  A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

  以下公式（I）所代表的嘧啶化合物对害虫具有出色的控制活性，并可用作杀虫剂的活性成分。
• PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL
  申请人：Mizuno Hajime

  公开号：US20120041009A1

  公开（公告）日：2012-02-16

  A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

  下面公式（I）所表示的嘧啶化合物具有优异的害虫控制活性，并且可用作害虫控制剂的活性成分。
• Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists
  作者：Stefan Peukert、Richard Hughes、Jill Nunez、Guo He、Zhao Yan、Rishi Jain、Luis Llamas、Sarah Luchansky、Adam Carlson、Guiqing Liang、Vidya Kunjathoor、Mike Pietropaolo、Jeffrey Shapiro、Anja Castellana、Xiaoping Wu、Avirup Bose

  DOI：10.1021/ml500240d

  日期：2014.10.9

  The identification of highly potent and orally bioavailable GPR39 agonists is reported. Compound 1, found in a phenotypic screening campaign, was transformed into compound 2 with good activity on both the rat and human GPR39 receptor. This compound was further optimized to improve ligand efficiency and pharmacokinetic properties to yield GPR39 agonists for the potential oral treatment of type 2 diabetes. Thus, compound 3 is the first potent GPR39 agonist (EC(50)s <= 1 nM for human and rat receptor) that is orally bioavailable in mice and robustly induced acute GLP-1 levels.