β-triphenylgermylmethylpropionic acid | 142208-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: β-triphenylgermylmethylpropionic acid
• 英文别名: 2-Methyl-3-triphenylgermylpropanoic acid
• CAS: 142208-36-4
• 化学式: C₂₂H₂₂GeO₂
• 分子量: 391.005
• InChiKey: LODCJLKFCOIYEL-UHFFFAOYSA-N

物化性质

• 沸点：
  496.7±47.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  β-triphenylgermylmethylpropionic acid 、 三(对甲基苯基)二溴化锑 在 triethylamine 作用下， 以 甲苯 为溶剂， 以85.4%的产率得到
  参考文献：
  名称：

  Synthesis, characterization and antitumor activity of some arylantimony triphenylgermanylpropionates and crystal structures of Ph3GeCH(Ph)CH2CO2SbPh4 and [Ph3GeCH2CH(CH3)CO2]2Sb(4-ClC6H4)3

  摘要：

  A series of novel arylantimony(V) triphenylgermanylpropionates with the formula ((Ph3GeCHRCHRCO2)-C-1-C-2)(n)SbAr(5-n) (R-1 = H, Ph; R-2 =H, CH3; n = 1, 2) were synthesized and characterized by elemental analysis, IR, H-1-NMR, C-13-NMR and mass spectroscopy. The crystal structures of Ph3GeCH(Ph)CH2CO2SbPh4 and [Ph3GeCH2CH(CH3)CO2](2)Sb(4-ClC6H4)(3) were determined by X-ray diffraction. The in vitro antitumor activities of some selected compounds against five cancer cells are reported. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(00)00799-3

文献信息

• Synthesis and structure of a bridging dimer of PhBi[O 2 CCH(CH 3 )CH 2 GePh 3 ] 2
  作者：Lin Yu、Yong-Qiang Ma、Run-Chang Liu、Guo-Cang Wang、Jin-Shan Li

  DOI：10.1016/j.inoche.2003.12.025

  日期：2004.3

  Abstract The novel compound PhBi[O2CCH(CH3)CH2GePh3]2 has been synthesized and characterized structurally. The molecular structure shows that both carboxylates are bidentate ligands and oxygen bridges between symmetrically related molecules link them into dimer.

  摘要 合成并表征了新型化合物PhBi[O2CCH(CH3)CH2GePh3]2。分子结构表明，两种羧酸盐都是双齿配体，对称相关分子之间的氧桥将它们连接成二聚体。
• Synthesis and structural characterization of several tris(2-methyl-2-phenylpropyl)tin carboxylates containing germanium
  作者：Xiaoniu Fang、Xueqing Song、Qinglan Xie

  DOI：10.1016/s0022-328x(00)00542-8

  日期：2001.1

  Thirteen tris(2-methyl-2-phenylpropyl)tin germylpropionates have been synthesized and their structures characterized by elemental analysis, IR, multinuclear NMR (1H, 13C, 119Sn) and MS spectroscopies. The structure of (PhC(CH3)2CH2)3SnO2CCH2CH(o-C6H4Cl)GePh3 has been determined by X-ray diffraction study, which indicated that the tin in the compound possess a tetrahedral geometry. Bioassay results

  合成了十三种三（2-甲基-2-苯基丙基）锡三甲基丙酸酯，并通过元素分析，IR，多核NMR（1 H，13 C，119 Sn）和MS光谱学对其结构进行了表征。通过X射线衍射研究确定了（PhC（CH 3）2 CH 2）3 SnO 2 CCH 2 CH（o -C 6 H 4 Cl）GePh 3的结构，表明该化合物中的锡具有四面体几何。生物测定结果表明，某些化合物具有良好的杀螨活性。
• Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures of (4-BrC6H4)3Bi(O2CCH2CH2GePh3)2 and (4-BrC6H4)3Bi[O2CCH(CH3)CH2GePh3]2
  作者：Lin Yu、Yong-Qiang Ma、Guo-Cang Wang、Jin-Shan Li、Guan-Hua Du、Juan-Juan Hu

  DOI：10.1016/s0022-328x(03)00547-3

  日期：2003.8

  A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi((O2CCHRCHRGePh3)-C-1-Ge-2)(2) (R-1 = H, CH3; R-2 = H, Ph; Ar = Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, H-1-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4)(3)Bi(O2CCH2CH2GePh3)(2) and (4-BrC6H4)(3)Bi[O2CCH(CH3)CH2GePh3](2) were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 muM show good in vitro antitumor activities. (C) 2003 Elsevier B.V. All rights reserved.