2-<5-Nitro-furfuryliden>-indandion-(1,3) | 52119-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-<5-Nitro-furfuryliden>-indandion-(1,3)
• 英文别名: 2-(5-Nitro-furfuryliden)-indandion-(1,3)；2-[(5-Nitro-2-furyl)methylene]cyclopenta[1,2-a]benzene-1,3-dione；2-[(5-nitrofuran-2-yl)methylidene]indene-1,3-dione
• CAS: 52119-08-1
• 化学式: C₁₄H₇NO₅
• 分子量: 269.213
• InChiKey: WGJMCYKEGRDHCY-UHFFFAOYSA-N

物化性质

• 熔点：
  214 °C
• 沸点：
  480.9±45.0 °C(Predicted)
• 密度：
  1.547±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-硝基糠醛 、 2-<5-Nitro-furfuryliden>-indandion-(1,3) 、 L-脯氨酸 以 1,4-二氧六环 为溶剂， 反应 0.42h， 以39%的产率得到
  参考文献：
  名称：

  Microwave-promoted, catalyst-free, multi-component reaction of proline, aldehyde, 1,3-diketone: one pot synthesis of pyrrolizidines and pyrrolizinones

  摘要：

  One-pot, three-component preparation of the pyrrolizidine and pyrrolizinone derivatives in moderate to good yield is reported. The synthesis is facilitated by microwave irradiation of proline, aromatic aldehyde, and 1,3-diketone such as 2-arylmethylene-indene-1,3-dione and 4-hydroxycoumarin in 1,4-dioxane or xylene. This method provides a quick access to the multi-functionalized pyrrolizidines and pyrrolizinones. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.12.056
• 作为产物：
  描述：

  5-硝基糠醛 、 1,3-茚满二酮 在 L-脯氨酸 作用下， 以 甲醇 为溶剂， 反应 15.0h， 以80%的产率得到2-<5-Nitro-furfuryliden>-indandion-(1,3)
  参考文献：
  名称：

  Microwave-promoted, catalyst-free, multi-component reaction of proline, aldehyde, 1,3-diketone: one pot synthesis of pyrrolizidines and pyrrolizinones

  摘要：

  One-pot, three-component preparation of the pyrrolizidine and pyrrolizinone derivatives in moderate to good yield is reported. The synthesis is facilitated by microwave irradiation of proline, aromatic aldehyde, and 1,3-diketone such as 2-arylmethylene-indene-1,3-dione and 4-hydroxycoumarin in 1,4-dioxane or xylene. This method provides a quick access to the multi-functionalized pyrrolizidines and pyrrolizinones. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.12.056

文献信息

• Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases
  申请人：Ansorge Siegfried

  公开号：US20070037752A1

  公开（公告）日：2007-02-15

  The invention relates to substances which specifically inhibit peptidases splitting ala-p-nitroanilide for use in medicine. The invention further relates to the use of at least one such substance or of a pharmaceutical or cosmetic composition containing at least one such substance for the prophylaxis and therapy of diseases, in particular the prophylaxis and therapy of diseases with an overshooting immune response (autoimmune diseases, allergies and transplant rejections), of other chronic inflammatory diseases, neuronal diseases and brain damages, skin diseases (acne and psoriasis, among others), tumor diseases and special virus infections (including SARS).