3-thio-n-butyl-5,6-diphenyl-1,2,4-triazine | 108957-67-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-thio-n-butyl-5,6-diphenyl-1,2,4-triazine
• 英文别名: 3-Butylsulfanyl-5,6-diphenyl-1,2,4-triazine
• CAS: 108957-67-1
• 化学式: C₁₉H₁₉N₃S
• 分子量: 321.446
• InChiKey: FJKXIWYBWSTJSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,6-二苯基-1,2,4-三嗪-3-硫醇 、 正溴丁烷 以96%的产率得到
  参考文献：
  名称：

  SHIBAMOTO SHINJI; NISHIMURA TAMIO, J. PHARM. SOC. JAP., 107,(1987) N 4, 301-307

  摘要：

  DOI：

文献信息

• Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents
  作者：Hamid Irannejad、Mohsen Amini、Fariba Khodagholi、Niloufar Ansari、Solaleh Khoramian Tusi、Mohammad Sharifzadeh、Abbas Shafiee

  DOI：10.1016/j.bmc.2010.04.097

  日期：2010.6.15

  The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-kappa B, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases. (C) 2010 Elsevier Ltd. All rights reserved.
• SHIBAMOTO SHINJI; NISHIMURA TAMIO, J. PHARM. SOC. JAP., 107,(1987) N 4, 301-307
  作者：SHIBAMOTO SHINJI、 NISHIMURA TAMIO

  DOI：——

  日期：——