tert-butyl (1S,2S)-1-((2-oxo-2-(pyren-3-yl)ethoxy)carbonyl)-2-hydroxypropylcarbamate | 1262723-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: tert-butyl (1S,2S)-1-((2-oxo-2-(pyren-3-yl)ethoxy)carbonyl)-2-hydroxypropylcarbamate
• 英文别名: (2-oxo-2-pyren-1-ylethyl) (2S,3S)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
• CAS: 1262723-05-6
• 化学式: C₂₇H₂₇NO₆
• 分子量: 461.514
• InChiKey: DCOJAINAIFABOV-OWJWWREXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl (1S,2S)-1-((2-oxo-2-(pyren-3-yl)ethoxy)carbonyl)-2-hydroxypropylcarbamate 在 水 作用下， 以 乙腈 为溶剂， 反应 0.47h， 生成 1-(hydroxyacetyl)pyrene 、 N-tert-butoxycarbonyl-L-allo-threonine
  参考文献：
  名称：

  1-Acetylpyrene with dual functions as an environment-sensitive fluorophore and fluorescent photoremovable protecting group

  摘要：

  A series of new fluorescent ester conjugates of carboxylic acids including amino acids was synthesized by coupling with an environment-sensitive fluorophore 1-acetylpyrene. Interestingly, the fluorescence properties of the ester conjugates and 1-acetylpyrene were found to be highly sensitive to its surrounding environment. The results obtained from the photolysis of the ester conjugates indicated that various factors like solvent, irradiation wavelength, and the structure of the conjugates govern the rate of the photocleavage. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.10.090
• 作为产物：
  描述：

  N-tert-butoxycarbonyl-L-allo-threonine 、 1-(溴乙酰)芘 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 1,4-二氧六环 为溶剂， 反应 8.0h， 以82%的产率得到tert-butyl (1S,2S)-1-((2-oxo-2-(pyren-3-yl)ethoxy)carbonyl)-2-hydroxypropylcarbamate
  参考文献：
  名称：

  1-Acetylpyrene with dual functions as an environment-sensitive fluorophore and fluorescent photoremovable protecting group

  摘要：

  A series of new fluorescent ester conjugates of carboxylic acids including amino acids was synthesized by coupling with an environment-sensitive fluorophore 1-acetylpyrene. Interestingly, the fluorescence properties of the ester conjugates and 1-acetylpyrene were found to be highly sensitive to its surrounding environment. The results obtained from the photolysis of the ester conjugates indicated that various factors like solvent, irradiation wavelength, and the structure of the conjugates govern the rate of the photocleavage. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.10.090

文献信息

• 1-Acetylpyrene with dual functions as an environment-sensitive fluorophore and fluorescent photoremovable protecting group
  作者：Avijit Jana、Sanghamitra Atta、Sujan K. Sarkar、N.D. Pradeep Singh

  DOI：10.1016/j.tet.2010.10.090

  日期：2010.12

  A series of new fluorescent ester conjugates of carboxylic acids including amino acids was synthesized by coupling with an environment-sensitive fluorophore 1-acetylpyrene. Interestingly, the fluorescence properties of the ester conjugates and 1-acetylpyrene were found to be highly sensitive to its surrounding environment. The results obtained from the photolysis of the ester conjugates indicated that various factors like solvent, irradiation wavelength, and the structure of the conjugates govern the rate of the photocleavage. (C) 2010 Elsevier Ltd. All rights reserved.