tert-butyl N-[2-[bis(pyridin-2-ylmethyl)amino]-2-oxoethoxy]carbamate | 1219975-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl N-[2-[bis(pyridin-2-ylmethyl)amino]-2-oxoethoxy]carbamate
• CAS: 1219975-44-6
• 化学式: C₁₉H₂₄N₄O₄
• 分子量: 372.424
• InChiKey: MNEBGWVOJLRHLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  93.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-[bis(pyridin-2-ylmethyl)amino]-2-oxoethoxy]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 生成 C₁₄H₁₆N₄O₂
  参考文献：
  名称：

  Development of a new protein labeling strategy, oxidation labeling. part 1: Preliminary evaluation and synthesis of tautomycin containing a metal coordinating unit

  摘要：

  In the current work we present Out preliminary evaluation of a new protein labeling strategy, namely oxidation labeling We found that a bis(2-picolyl) amine analogue coordinating Cu+ was able to oxidize histidine to oxo-histedine in a small peptide by generating reactive oxygen species upon exposure to hydrogen peroxide The bis(2-picolyl) amine unit was then incorporated into the natural product tautomycin via in oxime via an oxime linker. The compound, which showed good activity toward protein phosphatase 1 gamma (PP1 gamma), will be used in oxidation labeling studies with PP1 gamma (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.036
• 作为产物：
  描述：

  二甲基吡啶胺 、 叔丁氧羰基氨氧基乙酸 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 19.0h， 以63%的产率得到tert-butyl N-[2-[bis(pyridin-2-ylmethyl)amino]-2-oxoethoxy]carbamate
  参考文献：
  名称：

  Development of a new protein labeling strategy, oxidation labeling. part 1: Preliminary evaluation and synthesis of tautomycin containing a metal coordinating unit

  摘要：

  In the current work we present Out preliminary evaluation of a new protein labeling strategy, namely oxidation labeling We found that a bis(2-picolyl) amine analogue coordinating Cu+ was able to oxidize histidine to oxo-histedine in a small peptide by generating reactive oxygen species upon exposure to hydrogen peroxide The bis(2-picolyl) amine unit was then incorporated into the natural product tautomycin via in oxime via an oxime linker. The compound, which showed good activity toward protein phosphatase 1 gamma (PP1 gamma), will be used in oxidation labeling studies with PP1 gamma (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.036

文献信息

• Development of a new protein labeling strategy, oxidation labeling. part 1: Preliminary evaluation and synthesis of tautomycin containing a metal coordinating unit
  作者：Magne O. Sydnes、Atsushi Miyazaki、Minoru Isobe、Hiroshi Ohinata、Motoi Miyazu、Akira Takai

  DOI：10.1016/j.tet.2009.12.036

  日期：2010.2

  In the current work we present Out preliminary evaluation of a new protein labeling strategy, namely oxidation labeling We found that a bis(2-picolyl) amine analogue coordinating Cu+ was able to oxidize histidine to oxo-histedine in a small peptide by generating reactive oxygen species upon exposure to hydrogen peroxide The bis(2-picolyl) amine unit was then incorporated into the natural product tautomycin via in oxime via an oxime linker. The compound, which showed good activity toward protein phosphatase 1 gamma (PP1 gamma), will be used in oxidation labeling studies with PP1 gamma (C) 2010 Elsevier Ltd All rights reserved