6-hydroxy-6-methyl-N,N'-di-(2-methoxyphenyl)-4-oxo-2-phenylcyclohexane-1,3-dicarboxamide | 124227-43-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-hydroxy-6-methyl-N,N'-di-(2-methoxyphenyl)-4-oxo-2-phenylcyclohexane-1,3-dicarboxamide
• 英文别名: 4-hydroxy-4-methyl-6-oxo-2-phenyl-cyclohexane-1,3-dicarboxylic acid di-o-anisidide；4-Hydroxy-4-methyl-6-oxo-2-phenyl-cyclohexan-1,3-dicarbonsaeure-di-o-anisidid；4-hydroxy-N,N'-bis(2-methoxyphenyl)-4-methyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxamide；4-hydroxy-1-N,3-N-bis(2-methoxyphenyl)-4-methyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxamide
• CAS: 124227-43-6
• 化学式: C₂₉H₃₀N₂O₆
• 分子量: 502.567
• InChiKey: XXEKHPPXNABTKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-hydroxy-6-methyl-N,N'-di-(2-methoxyphenyl)-4-oxo-2-phenylcyclohexane-1,3-dicarboxamide 在 乙烷,三氯氟- 作用下， 以 溶剂黄146 为溶剂， 反应 3.0h， 以56%的产率得到6-methyl-N,N'-di-(2-methoxyphenyl)-4-oxo-2-phenyl-5-cyclohexene-1.3-dicarboximide
  参考文献：
  名称：

  Synthesis of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides and their reactions with p-toluidine and hydrazine hydrate

  摘要：

  Reaction of N-arylacetoacetamides with aromatic aldehydes in the presence of piperidine in ethanol afforded N,N',2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides. The latter reacted with p-toluidine leading to the formation of dehydration products. Reactions of N,N',2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate and cyanoacetic acid hydrazide gave rise to tetrahydroindazoles. Some of the obtained compounds showed antimicrobial activity.

  DOI：

  10.1134/s1070363215010089
• 作为产物：
  描述：

  邻甲氧基-N-乙酰乙酰苯胺 在 哌啶 作用下， 生成 6-hydroxy-6-methyl-N,N'-di-(2-methoxyphenyl)-4-oxo-2-phenylcyclohexane-1,3-dicarboxamide
  参考文献：
  名称：

  Pastour; Setier, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1957, vol. 244, p. 2808,2811

  摘要：

  DOI：

文献信息

• Synthesis and Antimicrobial Activity of Novel Hydrazone and 1,2,4-Triazole-3-thione Derivatives
  作者：A. N. Yankin、N. V. Nosova、V. V. Novikova、V. L. Gein

  DOI：10.1134/s1070363222020050

  日期：2022.2

  Abstract Novel hydrazone and 1,2,4-triazole-3-thione derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with acid hydrazides and thiosemicarbazide, respectively. Structure of the products was proved using IR and 1H NMR spectroscopy methods. Some of the synthesized compounds were tested for antimicrobial activity

  摘要 N 1 , N 3 ,2-三芳基-6-羟基-6-甲基-4-氧代环己烷-1,3-二甲酰胺与酸反应得到新型腙和1,2,4-三唑-3-硫酮衍生物酰肼和氨基硫脲。使用IR和1 H NMR光谱方法证明了产物的结构。测试了一些合成的化合物的抗微生物活性