4-(2-p-Tolyloxy-ethoxy)-piperidine | 77218-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-p-Tolyloxy-ethoxy)-piperidine
• 英文别名: 4-(2-(p-Tolyloxy)ethoxy)piperidine；4-[2-(4-methylphenoxy)ethoxy]piperidine
• CAS: 77218-14-5
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: DYDNSKOYURJUSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds and methods for CDK8 modulation and indications therefor
  申请人：Plexxikon Inc.

  公开号：US10703757B2

  公开（公告）日：2020-07-07

  Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, X3, X4, X5, X6, X7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

  公开了式 I 的化合物： 或其药学上可接受的盐、溶解物、同分异构体、异构体或氚代类似物，其中 R4、X3、X4、X5、X6、X7 和环 A 如本公开所述的任一实施方案中所述；其组合物；及其用途。
• COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20180215763A1

  公开（公告）日：2018-08-02

  Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R 4 , X 3 , X 4 , X 5 , X 6 , X 7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
• [EN] COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA MODULATION DE CDK8, ET INDICATIONS ASSOCIÉES
  申请人：PLEXXIKON INC

  公开号：WO2018136202A2

  公开（公告）日：2018-07-26

  Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, X3, X4, X5, X6, X7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.