1-n-nonylazacycloheptan-2-one | 59746-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-n-nonylazacycloheptan-2-one
• 英文别名: 1-Nonylazepan-2-one
• CAS: 59746-38-2
• 化学式: C₁₅H₂₉NO
• 分子量: 239.401
• InChiKey: OHQIBYGMOSXKPD-UHFFFAOYSA-N

物化性质

• 沸点：
  361.4±11.0 °C(Predicted)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-己内酯 、 壬胺 反应 20.0h， 以gave 11.5 g (26%) of product的产率得到1-n-nonylazacycloheptan-2-one
  参考文献：
  名称：

  Vehicle composition containing 1-substituted azacycloalkan-2-ones

  摘要：

  用于携带生理活性剂如治疗剂通过皮肤和其他身体膜的组成物包括该剂和一个有效的、无毒的化合物，其具有结构式 ##STR1## 其中R'是H或较低的烷基，m为3-7，N为0-17，R为-CH.sub.3，苯基或取代苯基或 ##STR2## 前提是如果m为3且R为-CH.sub.3，则n不是0-6。

  公开号：

  US04424210A1

文献信息

• Vehicle composition containing 1-substituted azacyclononan-2-ones
  申请人：Nelson Research & Development Company

  公开号：US04415563A1

  公开（公告）日：1983-11-15

  Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.

  用于携带生理活性剂如治疗剂通过皮肤和其他体膜的组合物，包括该剂和结构式##STR1##中具有有效的、无毒的化合物，其中R'为H或低碳基团，m为3-7，N为0-17，而R为--CH.sub.3，苯基或取代苯基或##STR2##，但如果m为3且R为--CH.sub.3，则n不为0-6。
• Vehicle composition containing 1-substituted azacycloalkan-2-ones
  申请人：Nelson Research & Development Company

  公开号：US04424210A1

  公开（公告）日：1984-01-03

  Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.

  用于携带生理活性剂如治疗剂通过皮肤和其他身体膜的组成物包括该剂和一个有效的、无毒的化合物，其具有结构式 ##STR1## 其中R'是H或较低的烷基，m为3-7，N为0-17，R为-CH.sub.3，苯基或取代苯基或 ##STR2## 前提是如果m为3且R为-CH.sub.3，则n不是0-6。
• Vehicle composition containing 1-substituted azacyclopentan-2-ones
  申请人：Nelson Research & Development Company

  公开号：US04444762A1

  公开（公告）日：1984-04-24

  Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.

  此处提供的是用于携带生理活性剂，如治疗剂，穿过皮肤和其他身体膜的组合物，其中包括该剂和具有结构式##STR1##的化合物的有效、无毒量，其中R'为H或较低的烷基，m为3-7，N为0-17，R为--CH.sub.3，苯基或取代苯基，或##STR2##，但如果m为3且R为--CH.sub.3，则n不为0-6。
• Topical methotrexate preparation for the treatment of hyperproliferative epithelial disease
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0247900A1

  公开（公告）日：1987-12-02

  Topical compositions containing methotrexate or its analogs and an effective skin penetration agent, as well as methods of its use in the topical treatment of hyperproliferative epithelial diseases, such as psoriasis.

  含有甲氨蝶呤或其类似物和一种有效的皮肤渗透剂的局部组合物，以及将其用于局部治疗增生性上皮疾病（如牛皮癣）的方法。
• Improved iontophoretic administration of drugs
  申请人：MACROCHEM CORPORATION

  公开号：EP0552879A1

  公开（公告）日：1993-07-28

  New and improved method for the transdermal administration of agents is provided utilizing iontophoresis in conjunction with a water-insoluble, stratum corneum-lipid modifier. The lipid modifier may be prior to iontophoresis or simultaneously therewith. The lipid modifier may be selected from a wide variety of moieties of the general formula R-X where R is a C₅ to C₂₈ alkyl or unsaturated alkyl and X is a member of the following: 1,3-dioxane; 1,3-dioxolane; lactam; morpholine; -COOH; -OH; -COOR'; -C-N(R')₂; cyclo ethylene and propylene carbonates; -CONH₂; -(CH₂-CH₂O)nH; acetals, and hemiacetals; and wherein R' is lower alkyl (e.g., C₁ to C₃) and n is an integer of from 1 to 20. Optionally there may be present a polar, water-soluble chemical compound from the group of alcohols, glycols, lactams, dioxolanes, esters, ureas, morpholine and the like. Compositions and articles useful in the processes of the present invention are also provided.

  本发明提供了一种新的、改进的透皮给药方法，利用离子透入法和一种不溶于水的角质层脂质改性剂。脂质修饰剂可以在离子透入之前使用，也可以与离子透入同时使用。脂质改性剂可选自多种通式 R-X 的分子，其中 R 为 C₅ 至 C₂₈ 烷基或不饱和烷基，X 为以下成员：1,3-二氧六环；1,3-二氧戊环；内酰胺；吗啉；-COOH；-OH；-COOR'；-C-N(R')₂；环乙烯和环丙烯碳酸盐；-CONH₂；-(CH₂-CH₂O)nH； 其中 R'为低级烷基（如 C₁ 至 C₃），n 为 1 至 20 的整数。可选择加入醇、乙二醇、内酰胺、二氧戊环、酯、脲、吗啉等极性水溶性化合物。还提供了本发明工艺中有用的组合物和物品。