2-氯-3-甲基丁-2-烯二酸 | 149230-79-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-氯-3-甲基丁-2-烯二酸
• 英文名称: cis-2-chloro-3-methylbutenedioic acid
• 英文别名: chloro-methyl-fumaric acid；Chlor-methyl-fumarsaeure；2-Chloro-3-methyl-2-butenedioic acid；(Z)-2-chloro-3-methylbut-2-enedioic acid
• CAS: 149230-79-5
• 化学式: C₅H₅ClO₄
• 分子量: 164.545
• InChiKey: OBQOLJUAOGDIIZ-IHWYPQMZSA-N

物化性质

• 沸点：
  328.7±27.0 °C(Predicted)
• 密度：
  1.568±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 barium dihydroxide 作用下， 生成 2-氯-3-甲基丁-2-烯二酸
  参考文献：
  名称：

  Michael; Tissot, Journal fur praktische Chemie (Leipzig 1954), 1895, vol. <2> 52, p. 340

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5HT6 RECEPTOR
  申请人：Grandel Roland

  公开号：US20100048582A1

  公开（公告）日：2010-02-25

  The invention relates to compounds of the formula (I) wherein the variables have meanings given in the claims and the description. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a 5HT 6 receptor ligand.

  本发明涉及公式（I）的化合物，其中变量的含义在权利要求书和说明书中给出。本发明还涉及使用公式I的化合物或其药学上可接受的盐来制备用于治疗可通过5HT6受体配体治疗的医疗紊乱的药物。
• HETEROCYCLIC ARYLSULPHONES SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5HT6 RECEPTOR
  申请人：Grandel Roland

  公开号：US20090306175A1

  公开（公告）日：2009-12-10

  The invention relates to compounds of the formula (I) wherein the variables have meanings given in the claims and the description. The invention also relates to the use of a compound of the formula (I) or a pharmaceutically acceptable salt thereof for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a 5HT 6 receptor ligand.

  本发明涉及化合物(I)的公式，其中变量的含义在权利要求和说明书中给出。本发明还涉及使用公式(I)的化合物或其药学上可接受的盐来制备用于治疗可通过5HT6受体配体治疗的医学疾患的药物。
• Method of retrieving elements from fixed tissue
  申请人：University of Houston System

  公开号：US10203269B2

  公开（公告）日：2019-02-12

  In some embodiments, the present disclosure pertains to a method for retrieving at least one molecular recognition element in a fixed tissue. In some embodiments the method comprises preparing a solution comprising at least one aldehyde-scavenging agent. In some embodiments, the method comprises contacting the fixed tissue with the solution. In some embodiments, the tissue is fixed with an aldehyde-based cross-linking agent. In some embodiments, a reaction of the aldehyde-scavenging agent with the aldehydes comprising the cross-linking agent retrieves the at least one molecular recognition element. In some embodiments, the at least one molecular recognition element comprises of amino acids, peptides, proteins, nucleic acids, carbohydrates, lipids, or a combination thereof. In some embodiments, the at least one aldehyde-scavenging agent comprises of beta-dicarbonyl compounds, mono or di-amide scavengers, ethyl alcohols, sulfur containing compounds, mercaptoethylamines, mercaptoethanols, hydrazines, ethanolamines, hydroxylamines, anilines, variation of amines, activated charcoal, phenols, or mixtures and combinations thereof.

  在某些实施方案中，本公开涉及一种在固定组织中检索至少一种分子识别元素的方法。在一些实施方案中，该方法包括制备包含至少一种醛清除剂的溶液。在某些实施方案中，该方法包括将固定组织与溶液接触。在某些实施方案中，用醛基交联剂固定组织。在某些实施方案中，醛基交联剂与包含交联剂的醛发生反应，回收至少一个分子识别元素。在一些实施方案中，至少一个分子识别元素包括氨基酸、肽、蛋白质、核酸、碳水化合物、脂类或它们的组合。在一些实施方案中，至少一种醛清除剂包括β-二羰基化合物、单酰胺或二酰胺清除剂、乙醇、含硫化合物、巯基乙胺、巯基乙醇、肼、乙醇胺、羟胺、苯胺、胺的变体、活性炭、酚或它们的混合物和组合。
• Aldehyde scavenging agent for retrieving elements from fixed tissue
  申请人：University of Houston System

  公开号：US10746637B2

  公开（公告）日：2020-08-18

  In some embodiments, the present disclosure pertains to a method for retrieving at least one molecular recognition element in a fixed tissue. In some embodiments the method comprises preparing a solution comprising at least one aldehyde-scavenging agent. In some embodiments, the method comprises contacting the fixed tissue with the solution. In some embodiments, the tissue is fixed with an aldehyde-based cross-linking agent. In some embodiments, a reaction of the aldehyde-scavenging agent with the aldehydes comprising the cross-linking agent retrieves the at least one molecular recognition element. In some embodiments, the at least one molecular recognition element comprises of amino acids, peptides, proteins, nucleic acids, carbohydrates, lipids, or a combination thereof. In some embodiments, the at least one aldehyde-scavenging agent comprises of beta-dicarbonyl compounds, mono or di-amide scavengers, ethyl alcohols, sulfur containing compounds, mercaptoethylamines, mercaptoethanols, hydrazines, ethanolamines, hydroxylamines, anilines, variation of amines, activated charcoal, phenols, or mixtures and combinations thereof.

  在某些实施方案中，本公开涉及一种在固定组织中检索至少一种分子识别元素的方法。在一些实施方案中，该方法包括制备包含至少一种醛清除剂的溶液。在某些实施方案中，该方法包括将固定组织与溶液接触。在某些实施方案中，用醛基交联剂固定组织。在某些实施方案中，醛基交联剂与包含交联剂的醛发生反应，回收至少一个分子识别元素。在一些实施方案中，至少一个分子识别元素包括氨基酸、肽、蛋白质、核酸、碳水化合物、脂类或它们的组合。在一些实施方案中，至少一种醛清除剂包括β-二羰基化合物、单酰胺或二酰胺清除剂、乙醇、含硫化合物、巯基乙胺、巯基乙醇、肼、乙醇胺、羟胺、苯胺、胺的变体、活性炭、酚或它们的混合物和组合。
• UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE
  申请人：University of Houston System

  公开号：EP3080610A1

  公开（公告）日：2016-10-19