methyl (3S,4S)-3-(benzyloxycarbonyl)amino-4-(tert-butoxycarbonyl)amino-6-methylheptanoate | 104021-83-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (3S,4S)-3-(benzyloxycarbonyl)amino-4-(tert-butoxycarbonyl)amino-6-methylheptanoate
• 英文别名: methyl (3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoate；(3S,4S)-methyl 3-(benzyloxycarbonylamino)-4-(tert-butoxycarbonylamino)-6-methylheptanoate；methyl (3S,4S)-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxycarbonylamino)heptanoate
• CAS: 104021-83-2
• 化学式: C₂₂H₃₄N₂O₆
• 分子量: 422.522
• InChiKey: GMAHPJLSCIDPCT-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl (3S,4S)-3-(benzyloxycarbonyl)amino-4-(tert-butoxycarbonyl)amino-6-methylheptanoate 生成 BOC-(3S,4S)Asta(Z)-OH
  参考文献：
  名称：

  RADDATZ, P.;SCHMITGES, C.

  摘要：

  DOI：
• 作为产物：
  描述：

  BOC-(3S,4S)Asta(Z)-OH 生成 methyl (3S,4S)-3-(benzyloxycarbonyl)amino-4-(tert-butoxycarbonyl)amino-6-methylheptanoate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Access to β,γ-diamino acids. Application to the synthesis of 3-deoxyaminostatine
  作者：Francelin Bouillère、Régis Guillot、Cyrille Kouklovsky、Valérie Alezra

  DOI：10.1039/c0ob00370k

  日期：——

  The synthesis of orthogonally protected diastereo- and enantiopure β,γ-diamino acids starting from natural α-amino acids is described, as well as its application to the synthesis of fully protected 3-deoxyaminostatine.

  介绍了从天然δ-氨基酸开始合成正交保护的非对映和对映纯δ²,δ³-二氨基酸的方法，以及该方法在合成完全保护的 3-脱氧氨基司他汀中的应用。
• Application of the N-hydroxymethyl group to the stereoselective synthesis of (3S,4S)-3-aminodeoxystatine derivatives
  作者：Dongwon Yoo、Seah Kwon、Young Gyu Kim

  DOI：10.1016/j.tetasy.2005.10.018

  日期：2005.11

  Stereo selective synthesis of two 3-aminodeoxystatine derivatives was achieved. Chiral gamma-amino-alpha,beta-unsaturated esters containing an N-aminomethyl group undergo the stereoselective conjugate addition with an internal carbamate or amide nitrogen nucleophile. The diastereoselectivity was about 10:1 by H-1 NMR. Thus, the 3-aminodeoxystatine derivatives were prepared from commercially available N-Boc-L-leucine in nine steps in overall yields of 26% and 20% for the benzyl carbamate and the acetamide derivatives, respectively. (c) 2005 Elsevier Ltd. All rights reserved.
• RADDATZ, P.;SCHMITGES, C.
  作者：RADDATZ, P.、SCHMITGES, C.

  DOI：——

  日期：——
• ——
  作者：RADDATZ P.、 HOLZEMANN G.、 JONCZYK A.、 SCHMITGES C. J.、 MINCK K. -O.、 RADU+

  DOI：——

  日期：——
• SCHOSTAREZ, HEINRICH J., J. ORG. CHEM., 53,(1988) N 15, 3628-3631
  作者：SCHOSTAREZ, HEINRICH J.

  DOI：——

  日期：——