10-[(2S)-3-chloro-2-methylpropyl]-10H-phenothiazine | 438458-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 10-[(2S)-3-chloro-2-methylpropyl]-10H-phenothiazine
• 英文别名: 10-[(2S)-3-chloro-2-methylpropyl]phenothiazine
• CAS: 438458-86-7
• 化学式: C₁₆H₁₆ClNS
• 分子量: 289.829
• InChiKey: DLUXZEDSVQWPOW-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吩噻嗪 、 (2rac)-{[(2R)-3-bromo-2-methylpropyl]oxy}tetrahydro-2H-pyran 以 四氢呋喃 、 水 为溶剂， 生成 10-[(2S)-3-chloro-2-methylpropyl]-10H-phenothiazine 、 10-[(2S)-2-methyl-3-(tetrahydro-2H-pyran-2-yloxy)propyl]-10H-phenothiazine
  参考文献：
  名称：

  2-(2-(4-((2r)-2-methyl-3-(10h-phenothiazin-10-yl)propyl)-1-piperazinyl)-ethoxy) ethanol, process for the preparation thereof, pharmaceutical compositions containing said compound and therapeutic uses thereof

  摘要：

  本发明涉及化合物2-(2-(4-((2R)-2-甲基-3-(10H-苯并噻唑-10-基)丙基)-1-哌嗪基)乙氧)乙醇及其药学上可接受的盐，以及其制备方法。本发明还涉及含有该化合物的药物组合物，以及其治疗用途。

  公开号：

  US20040072825A1

文献信息

• 2-(2-(4-((2R)-2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)-ETHOXY)ETHANOL, PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUND AND THERAPEUTIC USES THEREOF
  申请人：UCB, S.A.

  公开号：EP1345917A1

  公开（公告）日：2003-09-24
• [EN] 2-(2-(4-((2R)-2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)-ETHOXY)ETHANOL, PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUND AND THERAPEUTIC USES THEREOF<br/>[FR] 2-(2-(4-((2R)-2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)-ETHOXY)ETHANOL, PROCEDE DE PREPARATION ASSOCIE, COMPOSITIONS PHARMACEUTIQUES CONTENANT CE COMPOSE ET UTILISATION THERAPEUTIQUE DUDIT COMPOSE
  申请人：UCB SA

  公开号：WO2002050050A1

  公开（公告）日：2002-06-27

  The present invention relates to the compound 2-(2-(4-((2R)-2-methyl-3-(10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethoxy)ethanol, and its pharmaceutically acceptable salts, as well as to processes for the preparation thereof. It also relates to pharmaceutical compositions containing the said compounds, as well as to therapeutic uses thereof.
• 2-(2-(4-((2r)-2-methyl-3-(10h-phenothiazin-10-yl)propyl)-1-piperazinyl)-ethoxy) ethanol, process for the preparation thereof, pharmaceutical compositions containing said compound and therapeutic uses thereof
  申请人：——

  公开号：US20040072825A1

  公开（公告）日：2004-04-15

  The present invention relates to the compound 2-(2-(4-((2R)-2-methyl-3-(10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethoxy)ethanol, and its pharmaceutically acceptable salts, as well as to processes for the preparation thereof. It also relates to pharmaceutical compositions containing the said compounds, as well as to therapeutic uses thereof.

  本发明涉及化合物2-(2-(4-((2R)-2-甲基-3-(10H-苯并噻唑-10-基)丙基)-1-哌嗪基)乙氧)乙醇及其药学上可接受的盐，以及其制备方法。本发明还涉及含有该化合物的药物组合物，以及其治疗用途。