2,6-bis(1,4-diazapentyl)pyridine | 117013-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-bis(1,4-diazapentyl)pyridine
• 英文别名: N1,N1′-(pyridine-2,6-diylbis(methylene))bis(ethane-1,2-diamine)；N'-[[6-[(2-aminoethylamino)methyl]pyridin-2-yl]methyl]ethane-1,2-diamine
• CAS: 117013-61-3
• 化学式: C₁₁H₂₁N₅
• 分子量: 223.321
• InChiKey: AJFYQIAYHDKIST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  89
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,1-双(二乙氧基磷酰基)乙烯 、 2,6-bis(1,4-diazapentyl)pyridine 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

  摘要：

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.018
• 作为产物：
  描述：

  吡啶-2.6-二羧酸二甲酯 在 sodium tetrahydroborate 、 氯化亚砜 作用下， 以 甲醇 、 乙醇 、 苯 为溶剂， 生成 2,6-bis(1,4-diazapentyl)pyridine
  参考文献：
  名称：

  大环二氧戊胺：用于 1:1 镍 (II)-氧 (Ni(II)-O2) 加合物形成的新型配体

  摘要：

  La pentaaza-1,4,7,10,13 cyclohexadecanedione-14,16 forme des complexes stables 1:1 avec Ni(II) et Cu(II) possedant 2 donneurs deprotones en position equatoriale。Calcul des potentiels氧化还原。Cinetique de la fixation d'O 2 ensolutions aqueuses

  DOI：

  10.1021/ja00331a018

文献信息

• US5017274A
  申请人：——

  公开号：US5017274A

  公开（公告）日：1991-05-21
• Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation
  作者：Marcin Sawicki、Delphine Lecerclé、Gérard Grillon、Béatrice Le Gall、Anne-Laure Sérandour、Jean-Luc Poncy、Théodorine Bailly、Ramon Burgada、Marc Lecouvey、Vincent Challeix、Antoine Leydier、Stephane Pellet-Rostaing、Eric Ansoborlo、Frédéric Taran

  DOI：10.1016/j.ejmech.2008.01.018

  日期：2008.12

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.
• Macrocyclic dioxopentaamines: novel ligands for 1:1 nickel(II)-oxygen (Ni(II)-O2) adduct formation
  作者：Eiichi Kimura、Ryosuke Machida、Mutsuo Kodama

  DOI：10.1021/ja00331a018

  日期：1984.9

  La pentaaza-1,4,7,10,13 cyclohexadecanedione-14,16 forme des complexes stables 1:1 avec Ni(II) et Cu(II) possedant 2 donneurs deprotones en position equatoriale. Calcul des potentiels redox. Cinetique de la fixation d'O 2 en solutions aqueuses

  La pentaaza-1,4,7,10,13 cyclohexadecanedione-14,16 forme des complexes stables 1:1 avec Ni(II) et Cu(II) possedant 2 donneurs deprotones en position equatoriale。Calcul des potentiels氧化还原。Cinetique de la fixation d'O 2 ensolutions aqueuses