N-(2,3-dihydroxy-propyl)-2-methyl-acrylamide | 41601-36-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2,3-dihydroxy-propyl)-2-methyl-acrylamide
• 英文别名: N-(2,3-dihydroxypropyl)methacrylamide；DHPMAA；1-Methylacrylamidopropan-2,3-diol；2-Propenamide, N-(2,3-dihydroxypropyl)-2-methyl-；N-(2,3-dihydroxypropyl)-2-methylprop-2-enamide
• CAS: 41601-36-9
• 化学式: C₇H₁₃NO₃
• 分子量: 159.185
• InChiKey: QEFKKDIOPLIVGU-UHFFFAOYSA-N

物化性质

• 沸点：
  431.5±45.0 °C(Predicted)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基-1,2-丙二醇 、 甲基丙烯酸酐 在 三乙胺 作用下， 以 乙腈 为溶剂， 以30%的产率得到N-(2,3-dihydroxy-propyl)-2-methyl-acrylamide
  参考文献：
  名称：

  用于与基质金属蛋白酶 9 进行同工酶选择性相互作用的荧光水溶性聚合物

  摘要：

  基质金属蛋白酶 (MMP) 在各种病理条件下过度表达，包括癌症。尽管这些同工酶具有相似的活性位点，但它们表面暴露的氨基酸模式不同。在此，我们报告了两种水溶性荧光聚合物的合成和分子相互作用，与 MMP-7 和 -10 相比，它们显示出与 MMP-9 的选择性相互作用。

  DOI：

  10.1016/j.bmcl.2011.02.020

文献信息

• IONIC SILICONE HYDROGELS
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20130217620A1

  公开（公告）日：2013-08-22

  The present invention relates to ionic silicone hydrogel contact lenses which comprise at least one pharmaceutical or nutriceutical component and are formed from reaction mixtures comprising a mixture of slow-reacting hydrophilic monomers, including at least one slow-reacting ionic monomer, at least one silicone-containing component and at least one hydroxyl-containing component, wherein the ratio of the slow-reacting hydrophilic component half lives to the silicone-containing component half life is at least 2.

  本发明涉及离子硅氢凝胶隐形眼镜，其包括至少一种药用或营养成分，并由反应混合物形成，其包括缓慢反应的亲水性单体的混合物，包括至少一种缓慢反应的离子单体，至少一种含硅组分和至少一种含羟基组分，其中缓慢反应的亲水性组分半衰期与含硅组分半衰期的比率至少为2。
• Dispersion polymers processes for their preparation and their use
  申请人：Behringwerke Aktiengesellschaft

  公开号：US04945146A1

  公开（公告）日：1990-07-31

  The invention relates to dispersion polymers, processes for their preparation, and their use, and also active dispersion polymers (latex conjugates) prepared therefrom, the dispersion polymers being obtained by polymerizing compounds of the formula I H.sub.2 C.dbd.C(R.sub.1)--CO--NH--(CH.sub.2).sub.n --CH(OR.sub.2)(OR.sub.3)I in which n denotes 1-6; R.sub.1 denotes H or CH.sub.3 and R.sub.2 and R.sub.3 are identical or different and denote --(CH.sub.2).sub.m --CH.sub.3, m denotes 0-7, or --CY(X)(Z), in which X, Y and Z denote (CH.sub.2).sub.p CH.sub.3 and p denotes 1-3, where X, Y and Z are identical or different, and compounds of the formula II H.sub.2 C.dbd.C(R.sub.1)--CO--R--(CH.sub.2).sub.n --(CHOH).sub.m --(CH.sub.2).sub.l --H II in which R denotes O or NH; n denotes 1-3; m denotes 1-4; l denotes 0-4; and R.sub.1 denotes H or CH.sub.3, with one another in the presence of a seed dispersion, whereby the copolymer is formed on the surface of the latex particles. Latex conjugates are obtained therefrom by bonding the interesting antibodies or antigens to the dispersion polymers according to the invention.

  本发明涉及分散聚合物、其制备方法及其用途，以及由此制备的活性分散聚合物（乳胶共轭物）。所述分散聚合物是通过聚合式I化合物获得的，其中I为H.sub.2 C.dbd.C(R.sub.1)--CO--NH--(CH.sub.2).sub.n --CH(OR.sub.2)(OR.sub.3)，其中n为1-6；R.sub.1为H或CH.sub.3，R.sub.2和R.sub.3相同或不同，且为--(CH.sub.2).sub.m --CH.sub.3，m为0-7，或--CY(X)(Z)，其中X、Y和Z为(CH.sub.2).sub.p CH.sub.3，p为1-3，其中X、Y和Z相同或不同，以及式II化合物H.sub.2 C.dbd.C(R.sub.1)--CO--R--(CH.sub.2).sub.n --(CHOH).sub.m --(CH.sub.2).sub.l --H，其中R为O或NH；n为1-3；m为1-4；l为0-4；R.sub.1为H或CH.sub.3，在种子分散剂的存在下，它们相互聚合，从而形成共聚物在乳胶粒子的表面。根据本发明，可以将感兴趣的抗体或抗原与分散聚合物结合，从而获得乳胶共轭物。
• Method for the nephelometric or turbidimetric determination of proteins
  申请人：Behringwerke Aktiengesellschaft

  公开号：US05232859A1

  公开（公告）日：1993-08-03

  A method for the determination of a partner in an immunochemical reaction, in which one of the partners, which is dissolved in an aqueous fluid, is allowed to react with the other partner, which is covalently bonded to a solid phase, which comprises allowing the reaction to take place in the presence of 0.1 to 3 g/100 g of the aqueous fluid of a surfactant of the formula I CH.sub.3 --(CH.sub.2).sub.m --R--(CH.sub.2 --CH.sub.2 --O).sub.n --HI in which R is O, NH or CH.dbd.CH--(CH.sub.2).sub.p --O with m being 3-26, n being 7-40 and p being 5-15, and an agent suitable for this purpose, are described.

  本发明涉及一种在免疫化学反应中确定配对体的方法，其中溶解在水性液体中的一种配对体与共价键结合到固相上的另一种配对体反应，其中包括在存在0.1至3克/100克水性液体的表面活性剂I CH.sub.3 --(CH.sub.2).sub.m --R--(CH.sub.2 --CH.sub.2 --O).sub.n --HI下进行反应，其中R为O、NH或CH.dbd.CH--(CH.sub.2).sub.p --O，m为3-26，n为7-40，p为5-15，以及适合此目的的试剂。
• Antifouling material using hydroxyl group-containing acrylamide derivative and use thereof
  申请人：OKAZAKI Kouju

  公开号：US20080305292A1

  公开（公告）日：2008-12-11

  An antifouling material and an antifouling film, which are excellent in hydrophilicity and have such a characteristic that the surface is self-cleaned with rain water or the like, or can be easily cleaned up even when a contaminant adheres to the surface thereof, can be obtained by copolymerizing a composition containing an acrylamide derivative having at least one hydroxyl group in the molecule and a compound having at least two (meth)acryloyloxy groups in the molecule.

  一种防污材料和防污膜，具有极佳的亲水性，并具有这样的特性，即表面可以通过雨水等自我清洁，或者即使污染物附着在其表面上，也可以轻松清洁，通过共聚合含有至少一个羟基的丙烯酰胺衍生物和在分子中具有至少两个（甲基）丙烯酰氧基团的化合物的组合物可以获得该防污材料和防污膜。
• TERMINAL UNSATURATED, GLYCIDOL-BASED MACROMONOMERS, POLYMERS OBTAINABLE THEREFROM, PREPARATION AND USE
  申请人：Jaunky Wojciech

  公开号：US20120165414A1

  公开（公告）日：2012-06-28

  Process for preparing a macromonomer, in which a starting compound H 2 C═CR 1 —C 6 H 4-s (R 4 ) s —R 3 —OH or H 2 C═CR 2 —CO—NH—R 3 —OH, where R 1 and R 2 are each H or a linear or branched alkyl radical having from 1 to 4 carbon atoms, R 3 is a linear or branched alkylene, aralkylene radical which has from 1 to 20 carbon atoms and can contain one or more hydroxy groups and the radicals R 4 are each, independently of one another, a linear or branched alkyl, aralkyl, alkoxy or aralkoxy radical having from 1 to 20 carbon atoms and s=0-4, is, after partial deprotonation, reacted with at least one hydroxy-functional oxirane compound in the presence of an inhibitor of free-radical polymerization with opening of the oxirane ring, where the molar ratio of the molar amounts used n (starting compound) :n (oxirane compound) is in the range from 1:100 to 1:1. Macromonomers which can be obtained by the process, polymers which can be obtained therefrom and their use as additives in coating compositions, plastics and cosmetics.

  制备大分子单体的过程，其中起始化合物为H2C═CR1—C6H4-s(R4)s—R3—OH或H2C═CR2—CO—NH—R3—OH，其中R1和R2分别为H或具有1至4个碳原子的线性或支链烷基基团，R3为具有1至20个碳原子并且可以含有一个或多个羟基团的线性或支链烷基、芳基烷基基团，而基团R4则各自独立地为具有1至20个碳原子的线性或支链烷基、芳基烷基、烷氧基或芳氧基基团，其中s=0-4，经部分去质子化后，在自由基聚合抑制剂的存在下，与至少一种羟基官能团环氧化合物反应，开环，其中使用的摩尔量比n（起始化合物）：n（环氧化合物）在1:100至1:1范围内。可以通过该过程获得的大分子单体，可以从中获得的聚合物以及它们在涂料组合物、塑料和化妆品中的用途。