2-(2-phenylethyl)-3-methylfuran | 98761-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-phenylethyl)-3-methylfuran
• 英文别名: 3-Methyl-2-(2-phenylethyl)furan
• CAS: 98761-54-7
• 化学式: C₁₃H₁₄O
• 分子量: 186.254
• InChiKey: ABYURXIOODJRQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Lithium; (E)-4-bromo-6,6-diethoxy-1-phenyl-hex-4-en-3-olate 在 叔丁基锂 、 草酸 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 生成 2-(2-phenylethyl)-3-methylfuran
  参考文献：
  名称：

  (E)-1-Bromo-3,3-diethoxy-1-propene (diethyl acetal of 3-bromoacrolein). A versatile synthon for the synthesis of furans, butenolides, and (Z)-allyl alcohols

  摘要：

  DOI：

  10.1021/jo00224a044

文献信息

• Arsoniosilylation of α,β-unsaturated carbonyl compounds. Direct synthesis of furans from α,β-enals
  作者：Sunggak Kim、Yong Gil Kim

  DOI：10.1016/0040-4039(91)80647-o

  日期：1991.6

  Arsoniosilylation reactions of alpha,beta-enones and alpha,beta-enals have been studied by the low temperature H-1-NMR spectroscopy and direct synthesis of furans from alpha,beta-enals via arsoniosilylation is described.
• MEYERS, A. I.;SPOHN, R. F., J. ORG. CHEM., 1985, 50, N 24, 4872-4877
  作者：MEYERS, A. I.、SPOHN, R. F.

  DOI：——

  日期：——
• COMBINATION PRODUCT FOR THE INDUCTION AND/OR MAINTENANCE OF GENERAL ANESTHESIA
  申请人：BLUMENTECH, S.L.

  公开号：US20210186927A1

  公开（公告）日：2021-06-24

  The state of general anesthesia (GA) is essential to many surgical and medical procedures. This state is characterized by loss of consciousness, deep analgesia and suppression of movements. GA is rarely achieved with a single drug, usually requiring the combination of various pharmacological agents. Each drug can interact with one or more molecular targets affecting neuronal excitability and synaptic transmission in multiple regions of the CNS. Agonists of the μ-opioid receptor are commonly used in GA to cause analgesia, but not to induce or maintain loss of consciousness or movement suppression. Additionally, agonists of the μ-opioid receptor can cause serious unwanted side effects, e.g. respiratory depression. The present invention provides alternative combination products based on K-opioid receptor agonists. These combination products unexpectedly induced loss of consciousness, and were able to achieve and maintain GA. Furthermore, the combination products suppressed pain perception without the need of a μ-opioid receptor agonist. The combination of Salvinorin A, a selective κ-opioid receptor agonist, with Diazepam or Medetomidine surprisingly led to rapid consciousness, deep analgesia and movement suppression. This combination was found to effectively induce and maintain a state of general anesthesia.