bis-phenylacetyl-amine | 5330-40-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-phenylacetyl-amine
• 英文别名: Bis-phenylacetyl-amin；Symm. Diphenyl-diacetamid；2,2'-Diphenyl-diacetamid；Bis-phenylacetylamin；2-Phenyl-N-(phenylacetyl)acetamide；2-phenyl-N-(2-phenylacetyl)acetamide
• CAS: 5330-40-5
• 化学式: C₁₆H₁₅NO₂
• 分子量: 253.301
• InChiKey: RONVNKCYQBMEOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis-phenylacetyl-amine 在 盐酸 、 溶剂黄146 作用下， 生成 N-(2-苯基乙基)-苯乙酰胺
  参考文献：
  名称：

  Sugasawa; Tsuda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1935, vol. 55, p. 1044,1048;engl.Ref.S.194,197

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-苯基乙酰基)氨基甲酸乙酯 生成 bis-phenylacetyl-amine
  参考文献：
  名称：

  Diels, Chemische Berichte, 1903, vol. 36, p. 746

  摘要：

  DOI：

文献信息

• Studies on Nitrile Salts. I. Dimerization of Nitriles Having α-Hydrogen in the Presence of Hydrogen Chloride
  作者：Shozo Yanagida、Tetsuo Fujita、Masataka Ohoka、Ichiro Katagiri、Saburo Komori

  DOI：10.1246/bcsj.46.292

  日期：1973.1

  chloroacetonitrile was confirmed to be N-(α,α,β-trichloroethyl)chloroacetamidine hydrochloride. The scope and limitations of the dimerization reaction of nitriles having α-hydrogen with HCl were studied. Most nitriles having α-hydrogen react with HCl to give N-(α-chloroalkenyl)alkylamidine hydrochlorides (3). Their hydrolysis to diacylamines (4) was also investigated.

  重新研究了先前报道的几种稳定腈-HCl 盐的组成和结构。它们中的大多数已被发现具有 2RC≡N·2HCl 的组成，并已通过质量和 NMR 光谱分析确定为 N-(α-氯烯基) 烷基脒盐酸盐 (3)。然而，来自氯乙腈的 2:3 加合物被证实为 N-(α,α,β-三氯乙基) 氯乙脒盐酸盐。研究了含α-氢的腈与HCl的二聚反应的范围和局限性。大多数含有 α-氢的腈与 HCl 反应生成 N-(α-氯烯基) 烷基脒盐酸盐 (3)。还研究了它们水解成二酰胺 (4)。
• PIPERIDINE DERIVATIVE
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20190040039A1

  公开（公告）日：2019-02-07

  The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis , multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

  本发明的目的是提供一种对结核分枝杆菌、多药耐药结核菌和/或非结核性抗酸杆菌具有优异抗菌活性的化合物。可以利用由化学式[I]表示的化合物（在该化学式中，每个符号如所附规范所述），或其盐来诊断、预防和/或治疗结核病。
• PROCESS FOR PRODUCING CARBOXYLIC ACID FROM PRIMARY ALCOHOL
  申请人：IWABUCHI Yoshiharu

  公开号：US20090124806A1

  公开（公告）日：2009-05-14

  To provide an industrially-useful and environmentally-friendly novel oxidation reaction. A process for producing a carboxylic acid from a primary alcohol, which comprises using an alkali metal chlorite as a co-oxidizing agent and using, as a catalyst, an oxoammonium salt of the formula ( 1 ):

  提供一种在工业上有用且环保的新型氧化反应。从一种一级醇制备羧酸的方法，包括使用一种碱金属次氯酸盐作为共氧化剂，并使用一种催化剂，其化学式为（1）的氧胺盐。
• METHOD FOR PRODUCING 2-AZAADAMANTANE COMPOUND FROM BICYCLOCARBAMATE COMPOUND
  申请人：Kozawa Masami

  公开号：US20120053348A1

  公开（公告）日：2012-03-01

  To provide a novel method for producing a 2-azaadamantane compound from a bicyclocarbamate compound. In accordance with the following scheme: a bicyclocarbamate compound represented by the formula (1) is reacted with a halogenating agent to produce a 2-azaadamantane carbamate compound represented by the formula (2), and the 2-azaadamantane carbamate compound is subjected to hydrogenolysis to produce a 2-azaadamantane compound represented by the formula (3) (in the formulae, R 1 is hydrogen or the like, each of R 2 and R 3 which are independent of each other, is a hydrogen atom or a C 1-6 alkyl group, Ar is an aryl group which may be substituted by R a , R a is halogen or the like, X is a halogen atom, and Y is X or a hydrogen atom).

  提供一种从双环氨基甲酸酯化合物制备2-氮杂金刚烷化合物的新方法。根据以下方案：将式（1）表示的双环氨基甲酸酯化合物与卤代试剂反应，产生式（2）表示的2-氮杂金刚烷氨基甲酸酯化合物，然后对2-氮杂金刚烷氨基甲酸酯化合物进行氢解反应，产生式（3）表示的2-氮杂金刚烷化合物（在公式中，R1为氢或类似物，R2和R3各自独立地为氢原子或C1-6烷基，Ar为芳基基团，可能被Ra取代，Ra为卤素或类似物，X为卤素原子，Y为X或氢原子）。
• METHOD FOR PRODUCING 2-AZAADAMANTANE
  申请人：HAMADA Toshimasa

  公开号：US20120310005A1

  公开（公告）日：2012-12-06

  To provide a method whereby a 2-azaadamantane can easily be obtained in good yield. A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.

  提供一种方法，可以轻松地获得良好收率的2-氮杂金刚烷。一种制备2-氮杂金刚烷的方法，其包括在酸的存在下使下式(2)所代表的化合物环化。式(1)代表2-氮杂金刚烷。

表征谱图