2-(6-methoxypyridin-2-yl)-4-methylaniline | 1208348-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(6-methoxypyridin-2-yl)-4-methylaniline
• 英文别名: 2-(6-Methoxypyridin-2-yl)-4-methylaniline
• CAS: 1208348-06-4
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: LBIGLDOTJDLYOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(6-methoxypyridin-2-yl)-4-methylaniline 、 对氟苯甲醛 在 三氟乙酸 、 水 、 碳酸氢钠 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以89%的产率得到6-(4-fluorophenyl)-2-methyl-5,6-dihydro-8H-pyrido[1,2-c]quinazolin-8-one
  参考文献：
  名称：

  Regioselective intramolecular electrophilic substitution reactions involving π-deficient pyridine substrates: a new entry to pyridoquinazolines and benzo[h][1,6]naphthyridines

  摘要：

  Regioselective intramolecular electrophilic substitution reactions have been described in pi-deficient pyridine substrates tethered at C-2 to the aryl amine. The presence and nature of ring activating groups at C-6 led to the involvement of either N-1 or C-3 of the pyridine ring in the cyclization thereby leading to the regioselective synthesis of pyridoquinazolines and naphthyridines in excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.115
• 作为产物：
  描述：

  2-溴-6-甲氧基吡啶 、 2-氨基-5-甲基苯硼酸频那醇酯 在 bis-triphenylphosphine-palladium(II) chloride 、 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以82%的产率得到2-(6-methoxypyridin-2-yl)-4-methylaniline
  参考文献：
  名称：

  Regioselective intramolecular electrophilic substitution reactions involving π-deficient pyridine substrates: a new entry to pyridoquinazolines and benzo[h][1,6]naphthyridines

  摘要：

  Regioselective intramolecular electrophilic substitution reactions have been described in pi-deficient pyridine substrates tethered at C-2 to the aryl amine. The presence and nature of ring activating groups at C-6 led to the involvement of either N-1 or C-3 of the pyridine ring in the cyclization thereby leading to the regioselective synthesis of pyridoquinazolines and naphthyridines in excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.115

文献信息

• [EN] OXIM DERIVATIVES AS HSP90 INHIBITORS<br/>[FR] DÉRIVÉS D'OXIME EN TANT QU'INHIBITEURS DE HSP90
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009097578A1

  公开（公告）日：2009-08-06

  The invention relates to HSP90 inhibiting compounds consisting of the formula: (I) wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  本发明涉及具有式(I)结构的HSP90抑制化合物，其中变量如本文所定义。本发明还涉及包含此类化合物的药物组合物、套件和制造品；制备这些化合物的方法和中间体；以及使用这些化合物的方法。
• Regioselective intramolecular electrophilic substitution reactions involving π-deficient pyridine substrates: a new entry to pyridoquinazolines and benzo[h][1,6]naphthyridines
  作者：Piyush K. Agarwal、Mohammad Saifuddin、Bijoy Kundu

  DOI：10.1016/j.tet.2009.11.115

  日期：2010.1

  Regioselective intramolecular electrophilic substitution reactions have been described in pi-deficient pyridine substrates tethered at C-2 to the aryl amine. The presence and nature of ring activating groups at C-6 led to the involvement of either N-1 or C-3 of the pyridine ring in the cyclization thereby leading to the regioselective synthesis of pyridoquinazolines and naphthyridines in excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.