ALTERNAROSIDE B | 1184182-48-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ALTERNAROSIDE B
• 英文别名: (2R,3E)-2-hydroxy-N-[(2S,3R,4E,8E)-1-β-D-glucopyranosyloxy-3-hydroxy-9-methylheptadec-4,8-dien-2-yl]octadec-3-enamide；nor-cerebroside C；(E,2R)-2-hydroxy-N-[(2S,3R,4E,8E)-3-hydroxy-9-methyl-1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyheptadeca-4,8-dien-2-yl]octadec-3-enamide
• CAS: 1184182-48-6
• 化学式: C₄₂H₇₇NO₉
• 分子量: 740.075
• InChiKey: XYCVJZWQEQFSGR-MXVOGVNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  52
• 可旋转键数：
  32
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  甲醇 、 ALTERNAROSIDE B 在 盐酸 作用下， 以 水 为溶剂， 生成 甲基-Alpha-D-吡喃葡糖苷 、 methyl (2'R,3'E)-2'-hydroxyoctadec-3'-enoate
  参考文献：
  名称：

  Cerebrosides of the Halotolerant Fungus Alternaria raphani Isolated from a Sea Salt Field

  摘要：

  In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alteniaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 mu M..

  DOI：

  10.1021/np9002299

文献信息

• Cerebrosides of the Halotolerant Fungus <i>Alternaria raphani</i> Isolated from a Sea Salt Field
  作者：Wenliang Wang、Yi Wang、Hongwen Tao、Xiaoping Peng、Peipei Liu、Weiming Zhu

  DOI：10.1021/np9002299

  日期：2009.9.25

  In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alteniaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 mu M..