1-O-hexadecyl-2-(2,2,2-trifluoroethyl)glycerol | 100556-70-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-O-hexadecyl-2-(2,2,2-trifluoroethyl)glycerol
• 英文别名: 1-Propanol, 3-(hexadecyloxy)-2-(2,2,2-trifluoroethoxy)-；3-hexadecoxy-2-(2,2,2-trifluoroethoxy)propan-1-ol
• CAS: 100556-70-5
• 化学式: C₂₁H₄₁F₃O₃
• 分子量: 398.55
• InChiKey: GOSGFCZSOOIHGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  27
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-溴乙基二氯膦酸酯 、 1-O-hexadecyl-2-(2,2,2-trifluoroethyl)glycerol 生成 2-bromoethyl [3-hexadecoxy-2-(2,2,2-trifluoroethoxy)propyl] hydrogen phosphate
  参考文献：
  名称：

  BRACHWITZ, H.;LANGEN, P.;SCHILDT, J.

  摘要：

  DOI：

文献信息

• BRACHWITZ, H.;LANGEN, P.;SCHILDT, J.
  作者：BRACHWITZ, H.、LANGEN, P.、SCHILDT, J.

  DOI：——

  日期：——
• Synthesis and antiproliferative potency of 9-β-d-arabinofuranosyl-2-fluoroadenine phospholipid adducts
  作者：H. Brachwitz、J. Bergmann、Y. Thomas、T. Wollny、P. Langen

  DOI：10.1016/s0968-0896(99)00027-9

  日期：1999.6

  Three novel alkylphospholipid and four novel O-alkylglycerophospholipid derivatives of fludarabine (F-ara-AMP), known as a drug for the clinical treatment of chronic lymphocytic leukemia, were synthesized. The antiproliferative activity was determined in comparison to the parent nucleoside fludarabine in an immortalized but nontumorigenic human mammary epithelial cell line (H 154 A1N4), in two human breast tumor cell lines (MaTu and MCF7), and in two leukemic cell lines (HL 60 and Daudi). Fludarabine inhibited the growth of the leucemic cell lines very effectively. The breast tumor cell lines responded with much less sensitivity. The antiproliferative potency of the new compounds strongly depended on the chemical structure of the lipid component, and derivatives with a high effectiveness against one or both of the breast tumor cell lines were described. (C) 1999 Elsevier Science Ltd. All rights reserved.