bisbenzo[1,3]dioxol-5-ylmethanone | 4892-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bisbenzo[1,3]dioxol-5-ylmethanone
• 英文别名: bis(1,3-benzodioxol-5-yl)methanone；bis(benzo[d] [1,3]dioxol-5-yl)methanone；dibenzo[d][1,3]dioxol-5-ylmethanone；3,4;3',4'-bis-methylenedioxy-benzophenone；3,4-methylenedioxy-3',4'-methylenedioxybenzophenone；3,4;3',4'-Bis-methylendioxy-benzophenon；Bis(benzo[d][1,3]dioxol-5-yl)methanone
• CAS: 4892-35-7
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.241
• InChiKey: LSYMBIMGUYAOLS-UHFFFAOYSA-N

物化性质

• 熔点：
  140 °C(Solv: ethanol (64-17-5))
• 沸点：
  459.3±45.0 °C(Predicted)
• 密度：
  1.423±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  bisbenzo[1,3]dioxol-5-ylmethanone 在 aluminum isopropoxide 、 异丙醇 作用下， 生成 (1,3-benzodioxol-5-yl)-1,3-benzodioxole-5-methanol
  参考文献：
  名称：

  Garofano; Oliverio, Annali di Chimica, 1957, vol. 47, p. 986,907, 908

  摘要：

  DOI：
• 作为产物：
  描述：

  bis(benzo[d][1,3]dioxol-5-yl)methane 在 palladium on activated charcoal 、 水 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 48.0h， 以65%的产率得到bisbenzo[1,3]dioxol-5-ylmethanone
  参考文献：
  名称：

  烷基芳烃用水选择性氧化成芳香酮或苯甲醛

  摘要：

  这里报道了一种钯催化的氧化方法，用于将烷基芳烃转化为芳族酮或苯甲醛，水作为唯一的氧供体。这种 C-H 键氧化功能化不需要其他氧化剂和氢受体，H 2是唯一的副产物。通过对18 O-标记水反应的产物进行 MS 分析，确认了引入产物中的氧原子来自水。

  DOI：

  10.1021/acs.orglett.1c04154

文献信息

• Diphenylethylene compounds and uses thereof
  申请人：Muller W. George

  公开号：US20050107339A1

  公开（公告）日：2005-05-19

  The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

  本发明涉及二苯乙烯化合物和包含二苯乙烯化合物的组合物。本发明还涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗各种疾病和紊乱的方法。具体而言，该发明涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗癌症或炎症性紊乱的方法。本发明还涉及包含一种或多种二苯乙烯化合物的制品和工具包。
• Selenium-Catalyzed Trifluoromethylsulfinylation/Rearrangement of Allylic and Propargylic Alcohols: Access to Allylic and Allenic Triflones
  作者：Deng Zhu、Hui-Yun Luo、Zhi-Min Chen

  DOI：10.1021/acs.orglett.0c04236

  日期：2021.2.5

  A selenium-catalyzed trifluoromethylsulfinylation/rearrangement of allylic and propargylic alcohols for synthesizing triflones was developed for the first time. Various allylic and allenic triflones were delivered in moderate to excellent yields. After numerous control experiments were performed, it was suggested that this transformation includes an unusual [+SCF3] group disproportionation process

  首次开发了硒催化的三氟甲基亚磺酰基化/烯丙基和炔丙基醇的重排反应，用于合成三氟甲磺酸。各种烯丙基和艾伦三烯酮以中等至优异的产率递送。经过大量的控制实验后，有人认为这种转变包括一个不寻常的[ + SCF 3 ]基歧化过程，该过程形成了硒原位催化的[ + SOCF 3 ]，H 2 O被用作氧资源。该反应具有温和的反应条件和良好的底物相容性，并且不含过渡金属。
• Substituted quinazolines and analogs and use thereof
  申请人：Euro-Celtique S.A.

  公开号：US06465472B1

  公开（公告）日：2002-10-15

  The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.

  该发明涉及新型喹唑啉和杂环化合物，它们是AMPA受体的拮抗剂或正调节剂，用于治疗、预防或改善与中风、全脑和局部缺血、中枢神经系统创伤、低血糖和手术相关的神经元丧失，以及治疗或改善包括阿尔茨海默病、肌萎缩侧索硬化、亨廷顿病、帕金森病和唐氏综合征在内的神经退行性疾病，治疗、预防或改善兴奋性氨基酸过度刺激的不良后果，治疗、预防或改善焦虑、精神病、抽搐、慢性疼痛、青光眼、视网膜炎、尿失禁、肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏的不良后果，如精神分裂症、肌阵挛、阿尔茨海默病和营养不良和神经发育不良，以及作为认知和学习增强剂。
• Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral α-Oxa-Quaternary β-Haloketones
  作者：Zhi-Min Chen、Qing-Wei Zhang、Zhi-Hua Chen、Hui Li、Yong-Qiang Tu、Fu-Min Zhang、Jin-Miao Tian

  DOI：10.1021/ja201794v

  日期：2011.6.15

  A novel asymmetric halogenation/semipinacol rearrangement reaction catalyzed by cinchona alkaloid derivatives was developed. Two types of β-haloketones (X = Br, Cl) were obtained with up to 95% yield and 99% enantiomeric excess. The desired (+) and (-) enantiomers of the β-haloketones were readily obtained.

  开发了一种由金鸡纳生物碱衍生物催化的新型不对称卤化/半频哪醇重排反应。以高达 95% 的产率和 99% 的对映体过量获得了两种类型的 β-卤代酮 (X = Br, Cl)。很容易获得所需的 β-卤代酮的 (+) 和 (-) 对映异构体。
• Synthesis of Photolabile Dendrimer Cores
  作者：Dominic McGrath、Robert Kevwitch

  DOI：10.1055/s-2002-32530

  日期：——

  o-nitrobenzyl photolabile moieties have been synthesized from piperonal in five and eight steps, respectively. Methylated core analogs 6 and 13 undergo clean photocleavage as indicated by the evolution of isosbestic points in the UV spectra during photolysis and the observation of degradation products by 1 H NMR. These dendrimer cores serve as precursors to dendrimer-based photodegradable materials.

  两个树枝状大分子核，5 和 12，含有邻硝基苄基光不稳定部分，分别用五步和八步从胡椒醛合成。甲基化核心类似物 6 和 13 经历了干净的光裂解，如光解过程中紫外光谱中等吸收点的演变和通过 1 H NMR 观察降解产物所表明的那样。这些树枝状大分子核用作基于树枝状大分子的可光降解材料的前体。