N-(2-fluorophenyl)-N-methylacetamide | 120371-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-fluorophenyl)-N-methylacetamide
• 英文别名: N-(2-fluorphenyl)-N-methylacetamide
• CAS: 120371-27-9
• 化学式: C₉H₁₀FNO
• 分子量: 167.183
• InChiKey: DKJQSEBBYRMFKF-UHFFFAOYSA-N

物化性质

• 沸点：
  254.8±23.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三苯基氯硅烷 、 N-(2-fluorophenyl)-N-methylacetamide 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.08h， 以38%的产率得到N-(2-fluorophenyl)-N-methyl-2-(triphenylsilyl)acetamide
  参考文献：
  名称：

  Transition-Metal-Free Synthesis of Oxindoles by Potassium tert-Butoxide-Promoted Intramolecular α-Arylation

  摘要：

  Potassium tert-butoxide-mediated intramolecular alpha-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80 degrees C. In this manner, diversely substituted products have been obtained in moderate to high yields.

  DOI：

  10.1021/ol301704z
• 作为产物：
  描述：

  N-甲基-2-氟苯胺 、 乙酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以91%的产率得到N-(2-fluorophenyl)-N-methylacetamide
  参考文献：
  名称：

  Transition-Metal-Free Synthesis of Oxindoles by Potassium tert-Butoxide-Promoted Intramolecular α-Arylation

  摘要：

  Potassium tert-butoxide-mediated intramolecular alpha-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80 degrees C. In this manner, diversely substituted products have been obtained in moderate to high yields.

  DOI：

  10.1021/ol301704z

文献信息

• Carboxamide Compounds and Their Use
  申请人：Ben-Zeev Efrat

  公开号：US20100324035A1

  公开（公告）日：2010-12-23

  Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

  化学因子受体拮抗剂，特别是化合物式(I-A)的拮抗剂，作为化学因子CCR2受体的拮抗剂，包括其药物组合物和用途，用于治疗或预防与单核细胞聚集、淋巴细胞聚集或白细胞聚集相关的疾病。
• CARBOXAMIDE COMPOUNDS AND THEIR USE
  申请人：Lin Jian

  公开号：US20100210633A1

  公开（公告）日：2010-08-19

  Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

  本文介绍了化学因子受体拮抗剂，特别是公式(I)化合物，它们作为化学因子CCR2受体的拮抗剂，包括制药组合物及其用途，用于治疗或预防与单核细胞聚集、淋巴细胞聚集或白细胞聚集相关的疾病。
• DIHYDRONAPHTHYRIDINYL AND RELATED COMPOUNDS FOR USE IN TREATING OPHTHALMOLOGICAL DISORDERS
  申请人：Jones Simon

  公开号：US20100286136A1

  公开（公告）日：2010-11-11

  The invention provides methods of using dihydronaphthyridinyl and related compounds to treat opthalmological disorders, such as, wet age-related macular degeneration, diabetic retinopathy, and high myopia. Pharmaceutical compositions and methods of synthesizing the dihydronaphthyridinyl and related compounds are provided.

  本发明提供了使用二氢萘啶和相关化合物治疗眼科疾病的方法，例如湿性年龄相关性黄斑变性，糖尿病视网膜病变和高度近视。还提供了制备二氢萘啶和相关化合物的药物组合物和合成方法。
• An efficient and convenient method to prepare amides by the carbonylation of amines
  作者：Dejin Zhang、Shu Sun、Zehua Qian、Kangle Pei、Xueyu Shang、Chengcheng Liu、Pan Guo

  DOI：10.1016/j.tetlet.2022.154104

  日期：2022.9

  to the efficient and convenient synthesis of amides as their great application in medicinal chemistry. However, some problems still exist in the preparation of amides, such as atom-economic. Here, a new and efficient method to prepare amides by the carbonylation of amines was developed without CO gas and palladium catalyst. Mo(CO)6 was employed as carbonyl source, different amines could tolerate the

  酰胺类化合物在药物化学中的广泛应用对高效便捷地合成酰胺类具有重要意义。然而，酰胺的制备仍存在原子经济等问题。在这里，开发了一种在没有 CO 气体和钯催化剂的情况下通过胺的羰基化制备酰胺的新有效方法。采用Mo(CO) 6作为羰基源，不同的胺可以耐受反应条件，并以良好至优异的收率得到相应的酰胺。提出了一种可能的反应机理。该方法为酰胺的合成提供了一种潜在的途径。
• US4766243A
  申请人：——

  公开号：US4766243A

  公开（公告）日：1988-08-23