(R)-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]carbamic acid tert-butyl ester | 195621-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (R)-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]carbamic acid tert-butyl ester
• CAS: 195621-63-7
• 化学式: C₂₁H₂₉N₃O₄
• 分子量: 387.479
• InChiKey: RLRCKBMYKBFUFL-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  78.95
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]carbamic acid tert-butyl ester 在 盐酸 、 乙酸乙酯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 (R)-4-(3-{3-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]ureido}benzyloxycarbonylamino)butyric acid methyl ester
  参考文献：
  名称：

  Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with modified benzodiazepine skeletons

  摘要：

  Three different types of dual histamine H-2 and gastrin receptor antagonists, e.g. those bearing a benzazepine, benzoxazepine, or benzothiazepine skeleton instead of the benzodiazepine one as a gastrin receptor antagonistic moiety were synthesized to reduce high hydrophobicity of parent compounds and evaluated for the dual activities. These skeletal modifications significantly potentiated the binding affinity of dual antagonists with histamine H-2, receptor but markedly diminished their binding affinity with the gastrin receptor and the gastrin versus CCK-A receptor selectivity. We evaluated in vivo gastric acid antisecretory activities for some representative compounds by the rat pylorus ligation method for 10 mg kg(-1) dose by oral route. However, they exerted only low inhibitory activities for oral dose with % inhibition values ranging between 32 and 53%. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00075-8
• 作为产物：
  描述：

  ethyl 3-amino-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one-1-acetate 在 lithium hydroxide 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 (R)-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with modified benzodiazepine skeletons

  摘要：

  Three different types of dual histamine H-2 and gastrin receptor antagonists, e.g. those bearing a benzazepine, benzoxazepine, or benzothiazepine skeleton instead of the benzodiazepine one as a gastrin receptor antagonistic moiety were synthesized to reduce high hydrophobicity of parent compounds and evaluated for the dual activities. These skeletal modifications significantly potentiated the binding affinity of dual antagonists with histamine H-2, receptor but markedly diminished their binding affinity with the gastrin receptor and the gastrin versus CCK-A receptor selectivity. We evaluated in vivo gastric acid antisecretory activities for some representative compounds by the rat pylorus ligation method for 10 mg kg(-1) dose by oral route. However, they exerted only low inhibitory activities for oral dose with % inhibition values ranging between 32 and 53%. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00075-8

文献信息

• Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with modified benzodiazepine skeletons
  作者：Yasuyuki Kawanishi、Shoichi Ishihara、Tadahiko Tsushima、Kaoru Seno、Sanji Hagishita、Michio Ishikawa、Yasunobu Ishihara

  DOI：10.1016/s0968-0896(97)00075-8

  日期：1997.7

  Three different types of dual histamine H-2 and gastrin receptor antagonists, e.g. those bearing a benzazepine, benzoxazepine, or benzothiazepine skeleton instead of the benzodiazepine one as a gastrin receptor antagonistic moiety were synthesized to reduce high hydrophobicity of parent compounds and evaluated for the dual activities. These skeletal modifications significantly potentiated the binding affinity of dual antagonists with histamine H-2, receptor but markedly diminished their binding affinity with the gastrin receptor and the gastrin versus CCK-A receptor selectivity. We evaluated in vivo gastric acid antisecretory activities for some representative compounds by the rat pylorus ligation method for 10 mg kg(-1) dose by oral route. However, they exerted only low inhibitory activities for oral dose with % inhibition values ranging between 32 and 53%. (C) 1997 Elsevier Science Ltd.