N-(5-chloro-2-methoxyphenyl)-4-methyl-2-oxo-1H-quinoline-3-carboxamide | 1133824-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-chloro-2-methoxyphenyl)-4-methyl-2-oxo-1H-quinoline-3-carboxamide
• CAS: 1133824-18-6
• 化学式: C₁₈H₁₅ClN₂O₃
• 分子量: 342.782
• InChiKey: DVPDOUXHTCLGGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid imidazolide 、 5-氯-2-甲氧基苯胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 N-(5-chloro-2-methoxyphenyl)-4-methyl-2-oxo-1H-quinoline-3-carboxamide
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 142. 4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides as potential diuretics

  摘要：

  A large series of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides has been prepared as potential diuretic agents. The effect of all of the synthesized compounds on the urinary function of the kidney has been investigated. The appearance of a "structure - diuretic activity" relationship is discussed.

  DOI：

  10.1007/s10593-008-0029-1

文献信息

• 4-Hydroxy-2-quinolones 142. 4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides as potential diuretics
  作者：I. V. Ukrainets、N. L. Bereznyakova、V. A. Parshikov、O. I. Naboka

  DOI：10.1007/s10593-008-0029-1

  日期：2008.2

  A large series of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides has been prepared as potential diuretic agents. The effect of all of the synthesized compounds on the urinary function of the kidney has been investigated. The appearance of a "structure - diuretic activity" relationship is discussed.