3-t-butyl-5,5-dimethylhydantoin | 63989-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-t-butyl-5,5-dimethylhydantoin
• 英文别名: 3-tert-butyl-5,5-dimethyl-imidazolidine-2,4-dione；3-tert.Butyl-5,5-dimethyl-2,4-imidazolindion；3-Tert-butyl-5,5-dimethylimidazolidine-2,4-dione
• CAS: 63989-64-0
• 化学式: C₉H₁₆N₂O₂
• 分子量: 184.238
• InChiKey: PJKUTNUXUOPIRY-UHFFFAOYSA-N

物化性质

• 熔点：
  147-148 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
• 密度：
  1.062±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  溴代叔丁烷 、 5,5-二甲基海因 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 3-t-butyl-5,5-dimethylhydantoin
  参考文献：
  名称：

  Uscumlic, Gordana S.; Drmanic, Sasa Z.; Krstic, Vera V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 2, p. 193 - 195

  摘要：

  DOI：

文献信息

• Compounds Useful for Promoting Protein Degradation and Methods Using Same
  申请人：Yale University

  公开号：US20160022642A1

  公开（公告）日：2016-01-28

  The present description includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain embodiments, the description includes a compound comprising a protein degradation moiety covalently bound to a linker, wherein the ClogP of the compound is equal to or higher than 1.5. The target protein contemplated within the description comprises an androgen receptor. Compounds of the present description may be used to treat disease states wherein protein degradation is a viable therapeutic approach, such as cancer or any sort of oxidative stress disease state.

  本描述包括作为目标蛋白质降解剂的化合物，其中降解与目标蛋白质的类别或其定位无关。在某些实施例中，描述包括一种化合物，其中蛋白质降解基团与连接剂共价结合，该化合物的ClogP等于或高于1.5。描述中考虑的目标蛋白质包括雄激素受体。本描述的化合物可用于治疗蛋白质降解是可行治疗方法的疾病状态，如癌症或任何一种氧化应激疾病状态。
• ORGANIC COMPOUNDS AND THEIR USES
  申请人：Brandl Trixl

  公开号：US20100204159A1

  公开（公告）日：2010-08-12

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

  本申请描述了对人类疾病的治疗、预防和/或改善有用的有机化合物。
• SAI KEUNG CHIU; DUBE M.; KEIFER L.; SZILAGYI S.; TIMBERLAKE J. W., J. ORG. CHEM. <JOCE-AH>, 1978, 43, NO 1, 61-65
  作者：SAI KEUNG CHIU、 DUBE M.、 KEIFER L.、 SZILAGYI S.、 TIMBERLAKE J. W.

  DOI：——

  日期：——
• Organic Compounds and Their Uses
  申请人：Brandl Trixi

  公开号：US20070286842A1

  公开（公告）日：2007-12-13

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
• BIOCIDAL FIBERS
  申请人：Sun Gang

  公开号：US20090197084A1

  公开（公告）日：2009-08-06

  The present invention provides graft biocidal N-halamine polymers. The biocidal polymers are prepared by contacting precursor graft polymers with a halogen source. The precursor graft polymers are prepared by grafting a polymer, such as a polyolefin, with a vinyl monomer under suitable conditions, for example, a reactive extrusion condition. In one embodiment, the graft polymerization is carried out in the presence of a vinyl monomer and a radical initiator. The biocidal polymers have potent antimicrobial activities against a broad spectrum of microorganisms and virus, such as E. coli and flu viruses.